Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics  

作　　者：Joshua J.Gooley Eric Chern-Pin Chua 

机构地区：[1]Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School,Singapore [2]Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital [3]Division of Sleep Medicine, Harvard Medical School [4]Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore

出　　处：《Journal of Genetics and Genomics》2014年第5期231-250,共20页遗传学报（英文版）

基　　金：supported by the Duke-NUS Signature Research Program funded by the Agency for Science,Technology,and Research,Singapore,and the Ministry of Health,Singapore;the SingHealth Foundation(SHF),Singapore,under SHF/FG410P/2009

摘　　要：The circadian timing system plays a key role in orchestrating lipid metabolism. In concert with the solar cycle, the circadian system ensures that daily rhythms in lipid absorption, storage, and transport are temporally coordinated with rest-activity and feeding cycles. At the cellular level, genes involved in lipid synthesis and fatty acid oxidation are rhythmically activated and repressed by core clock proteins in a tissue-specific manner. Consequently, loss of clock gene function or misalignment of circadian rhythms with feeding cycles （e.g., in shift work） results in impaired lipid homeostasis. Herein, we review recent progress in circadian rhythms research using lipidomics, i.e., large-scale profiling of lipid metabolites, to characterize circadian-regulated lipid pathways in mammals. In mice, novel regulatory circuits involved in fatty acid metabolism have been identified in adipose tissue, liver, and muscle. Extensive diversity in circadian regulation of plasma lipids has also been revealed in humans using lipidomics and other metabolomics approaches. In future studies, lipidomics platforms will be increasingly used to better understand the effects of genetic variation, shift work, food intake, and drugs on circadian-regulated lipid pathways and metabolic health.The circadian timing system plays a key role in orchestrating lipid metabolism. In concert with the solar cycle, the circadian system ensures that daily rhythms in lipid absorption, storage, and transport are temporally coordinated with rest-activity and feeding cycles. At the cellular level, genes involved in lipid synthesis and fatty acid oxidation are rhythmically activated and repressed by core clock proteins in a tissue-specific manner. Consequently, loss of clock gene function or misalignment of circadian rhythms with feeding cycles （e.g., in shift work） results in impaired lipid homeostasis. Herein, we review recent progress in circadian rhythms research using lipidomics, i.e., large-scale profiling of lipid metabolites, to characterize circadian-regulated lipid pathways in mammals. In mice, novel regulatory circuits involved in fatty acid metabolism have been identified in adipose tissue, liver, and muscle. Extensive diversity in circadian regulation of plasma lipids has also been revealed in humans using lipidomics and other metabolomics approaches. In future studies, lipidomics platforms will be increasingly used to better understand the effects of genetic variation, shift work, food intake, and drugs on circadian-regulated lipid pathways and metabolic health.

关 键 词：CIRCADIAN METABOLISM LIPIDS LIPIDOMICS Metabolomics CHRONOBIOLOGY 

分 类 号：Q591.5[生物学—生物化学]