水溶性硫硒化镉量子点纳米颗粒对小鼠皮肤渗透性的影响  

Study the transdermal delivery capacity of water-soluble CdSeS quantum dots nanoparticles through mouse skin

作　　者：唐蕾[1] 宋光明[2] 曹瑾[3] 张春玲[4] 

机构地区：[1]武警后勤学院电子电工教研室,天津300309 [2]武警后勤学院药理学教研室,天津300309 [3]武警后勤学院数学教研室,天津300309 [4]南开大学物理科学学院,天津300071

出　　处：《武警后勤学院学报（医学版）》2014年第5期369-372,F0002,共5页Journal of Logistics University of PAP（Medical Sciences）

基　　金：武警后勤学院重点项目(WYZ201003)

摘　　要：【目的】研究水溶性硫硒化镉(CdSeS)量子点纳米颗粒对小鼠皮肤渗透性的影响。【方法】在雄性ICR鼠背部脱毛部位涂抹直径约为5 nm,发光波长为620 nm的量子点0.32 nmol,利用荧光显微镜和透射电镜对施药皮肤部位显微观察皮肤渗透性。【结果】荧光显微像显示量子点能够堆积在皮肤的表皮层中和真皮层的毛囊和腺体中,透射电镜显示量子点附着在皮肤表面和吸附在角质细胞的两侧。【结论】量子点纳米颗粒对小鼠皮肤具有一定渗透性,而且随着施加量子点溶液时间加长,渗透量略有增加,但是主要聚集在皮肤表面和角质层细胞的两侧。[ Objective ] To study the transdermal delivery capacity of water-soluble CdSeS quantum dots （QDs） nanoparticles through mouse skin. [ Methods ] QDs solution （0.32 nmol） was coated on the dorsal hairless skin of male ICR mice. Fluorescence microscope and transmission electron microscope（TEM） were used to observe the distribution of QDs in the skin. [ Results ] The fluorescence mi- croscopy images show that QDs could deposite on the skin, the epidermis and dermis layers of the hair follicles and glands, and TEM further demonstrated that quantum dots were attached to the skin surface and adsorbed on both sides of stratum corneum layers. [ Conclusion ] QDs had permeability on mouse skin and penetration increased slightly with time. Most of the QDs deposite on the skin surface, some QDs could penetrate into the dermal layer and were limited to the uppermost stratum corneum layers and the hair follicles.

关 键 词：量子点 纳米颗粒 透皮吸收 荧光显微镜 透射电镜 

分 类 号：R36[医药卫生—病理学]