41例钙化上皮瘤细胞病理学特征  

Cytomorphology properties for calcifying epitheliomas: Analysis in 41 cases

作　　者：杨海燕[1,2] 陈颖[1] 

机构地区：[1]复旦大学附属肿瘤医院病理科,复旦大学上海医学院肿瘤学系,上海200032 [2]安庆市立医院病理科,安徽安庆246003

出　　处：《皖南医学院学报》2014年第3期249-251,255,共4页Journal of Wannan Medical College

摘　　要：目的：总结钙化上皮瘤的细针针吸检查细胞学特征,提高细胞病理医师对其认识。方法：回顾性分析41例钙化上皮瘤患者的针吸标本,从涂片背景、肿瘤细胞形态特征等方面总结,并与相应组织病理学结果（13例）进行对照。结果：63%的病例发病年龄在30岁以下,男性占优势,好发于头颈部,肿块直径0.3-2.3 cm,均为单发。穿刺涂片显示95%（39/41）可见基底样细胞,常成片、成巢或散在排列,细胞边界不清,浆少,圆形、卵圆形核,染色质细腻,常见明显中位核仁;约76%（31/41）可见影细胞,成巢或散在排列,中心淡染;约34%（14/41）可见鳞状细胞样细胞。背景中常见到裸露的基底细胞核、多核巨细胞、角化物、钙化、炎细胞及碎屑样坏死。结论：钙化上皮瘤具有典型的细胞病理学特征;经验的总结和临床特点分析将有助于诊断。Objective： To investigate the cytomrophological features of calcifying epithelioma for improving the cytopathologist＇s perspective on identification of this tumor. Methods： Forty-one specimens obtained via fine needle aspiration in patients with calcifying epitheliomas were reviewed concerning the background of smears and cytomorphological nature,and compared with the histopathological findings in another 13 cases /controls. Results： 63% of the calcifying epithelioma occurred in patients under 30 years of age and most in males. The pathological lesion was more frequent at head and neck,and the tumor was solitary and commonly sized between 0. 3 and 2. 3 cm in diameter. The cytological smears presented with basaloid cells in 95%（ 39 /41） of the cases,and the cells were arranged in cluster,nest or dispersal fashion,with unclearly defined boundary,less cytoplasm,round to oval nuclei and fine chromatin,and one central nucleolus was frequently seen. Shadow cells arranged nest and dispersal pattern with pale cytoplasm were seen in 76%（ 31 /41） of the tumor cases and 34%（ 14 /41） revealed squamous cells. Naked nuclei,multinucleate giant cells,anucleated squames,calcification,inflammatory cells and debris were commonly identified against the background of smear. Conclusion： Calcifying epithelioma is characterized by typical cytopathological property,and wealthy experience and careful clinical examination may contribute to conclusive diagnosis of this entity.

关 键 词：钙化上皮瘤 病理学 诊断 

分 类 号：R735.9[医药卫生—肿瘤]