腺苷A2A受体与神经系统疾病  

Adenosine A_(2A) receptor and nervous system diseases

作　　者：王美亮[1,2] 俞纲[2] 苏瑞斌[1,2] 

机构地区：[1]广西医科大学药学院,南宁530021 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《国际药学研究杂志》2014年第3期287-290,317,共5页Journal of International Pharmaceutical Research

基　　金：国家“重大新药创制”科技重大专项资助项目(2012ZX09301003-001)

摘　　要：作为一种重要的神经递质,腺苷能通过与细胞膜上的腺苷受体(adenosine receptors,AR)结合而发挥细胞调节作用。AR属于G蛋白偶联受体家族,哺乳动物的AR至少包含A1、A2A、A2B和A3等4个亚型,其中A2A受体与多种临床疾病的发生、发展都有着密切的关系。本文主要综述了A2A受体与多种神经精神疾病之间关系的研究进展,以期为这些疾病的防治研究提供新的线索。Adenosine, which arises from the breakdown of adenosine triphosphate, is extensively distributed in mammalian tis-sues and cells. Adenosine exerts its regulating effects on cell function via binding to the specific membrane receptors. Adenosine receptors are belong to G-protein-coupled receptors and can be subdivided into A1, A2A, A2B and A3 receptors in mammals. Among these receptors, A2A has been demonstrated to be related to pathogenesis of many diseases. In the present review, we focus on the recent progress made in investigating the relationship between A2A and nervous system disorders, which may provide new strategies for treatment of these diseases.

关 键 词：腺苷A2A受体 神经系统 

分 类 号：R964[医药卫生—药理学]