米氮平与舍曲林治疗老年抑郁症的比较研究  

Comparative study of Mirtazapine and Sertraline in treatment of geriatric depression

作　　者：王学燕[1] 牛艳 杨红梅[1] 孙丽丽[1] 梁家騋[1] 

机构地区：[1]济南市精神卫生中心,山东济南250032 [2]山东枣庄市立第二医院

出　　处：《中国民康医学》2014年第10期26-27,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨米氮平和舍曲林治疗老年抑郁症的疗效及安全性。方法:将60例首发老年抑郁症患者(年龄≥60岁)随机分成两组,每组30例。两组患者分别应用米氮平和舍曲林治疗8周,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评定疗效和不良反应。结果:治疗后两组患者HAMD和HAMA评分较治疗前均有显著下降(P<0.01)。两组患者间比较,1周末和2周末米氮平组HAMD和HAMA评分减分较舍曲林组有显著差异(P<0.05),4周末和8周末评分,两组无显著差异(P>0.05)。苯二氮类药物使用舍曲林组患者显著多于米氮平组(P<0.01)。不良反应:舍曲林组患者恶心、睡眠及性功能障碍显著多于米氮平组(P<0.01);而米氮平组患者食欲增加和体质量增显著多于舍曲林组(P<0.05)。结论:米氮平和舍曲林治疗老年抑郁症疗效相当,而米氮平起效更快,不良反应少,依从性高,更适宜老年患者。Objective：To explore and study the efficacy and safety of Mirtazapine and Sertraline in treatment of geriatric depression.Methods：60 old patients（≥60 years old） suffering from first-episode depression were randomly divided into two groups（30 patients in each group）.The two groups were treated with Mirtazapine and Sertraline for eight weeks,respectively.Hamilton＇s depression scale（HAMD）,Hamilton anxiety scale（HAMA） and treatment emergent symptom scale（TESS） were used to evaluate the efficacy and the side effects.Results：After the treatment,the scores of HAMD and HAMA of the two groups both decreased greatly（P 0.01）.On the first and second weekends of the treatment,there were significant differences in the decrease of the scores of HAMD and HAMA between Mirtazapine group and Sertraline group（P 0.05）; however,on the fourth and eighth weekends of the treatment,there were no differences in the decrease of the scores of HAMD and HAMA between Mirtazapine group and Sertraline group（P 0.05）.The use of benzodiazepines of Sertraline group was significantly more than that of Mirtazapine group（P 0.01）.For the side effects,nausea,sleep and sexual dysfunction of the Sertraline group were more than those of the Mirtazapine group（P 0.01）; while increased appetite and weights of Sertraline group were lower than those of the Mirtazapine group（P 0.05）.Conclusions：Mirtazapine and Sertraline have the equivalent therapeutic effects in the treatment of geriatric depression,while Mirtazapine works faster with fewer adverse reactions and higher compliance,so it is more suitable for the elderly patients.

关 键 词：米氮平 舍曲林 老年抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学]