女性患者围术期肺血栓栓塞症与体质量指数相关性研究  

Study on correlation between perioperative pulmonary thromboembolism and body mass index in female patients

作　　者：程波[1] 闵苏[1] 魏珂[1] 黎平[1] 何开华[1] 曹俊[1] 熊秋菊[1] 

机构地区：[1]重庆医科大学附属第一医院麻醉科,重庆400016

出　　处：《重庆医学》2014年第18期2257-2259,2263,共4页Chongqing medicine

基　　金：国家临床重点专科建设项目(2011);重庆市科委科技攻关项目(cstc2012gg-yyjsl0053);重庆市卫生局面上项目(2011-2-006)

摘　　要：目的：探讨女性患者围术期肺血栓栓塞症（PE）发生率与体质量指数（BMI）的相关性。方法对2001～2012年该院140例女性手术患者并发PE临床资料进行回顾性研究，其中57例特发性 PE，83例非特发性 PE（与手术创伤以及恶性肿瘤有关）。BMI分为6个等级：＜22．5、22．5～＜25．0、25．0～＜27．5、27．5～＜30．0、30．0～＜35．0、≥35．0 kg/m2。多变量 Cox比例危险度模型变量有年龄、吸烟、生产次数、绝经期，药物摄入包括非甾类抗炎药、华法林使用情况，合并症包括原发性高血压、冠心病。结果 BMI与特发性PE（RR＝1．08，95％CI：1．06～1．10，P＜0．01）和非特发性 PE（RR＝1．08，95％CI：1．07～1．10，P＜0．01），均有较强的直线相关性。当BMI ≥35 kg/m2，危险度增加6倍。结论女性 BMI增加与 PE的发生有显著的线性相关， BMI可作为评估围术期PE的危险因素。Objective To study the correlation between the occurrence rate of perioperative pulmonary thromboembolism（PE） and the body mass index（BMI）in female patients.Methods 140 operative female cases complicating PE in this hospital from 2001 to 2012 were retrospectively studied.57 cases were idiopathic PE and 83 cases were non-idiopathic PE（related with surgery,trau-ma,and malignancy）.BMI was divided into 6 levels：＆lt;22.5,22.5-＆lt;25.0,25.0-＆lt;27.5,27.5-＆lt;30.0,30.0-＆lt;35.0,≥ 35.0 kg/m2 .The multivariate Cox proportional hazards model variable included age,smoking,parturition times,menopause,drug intake of non-steroidal anti-inflammatory drugs,warfarin,coexisting diseases including hypertension,coronary heart disease.Results BMI had stronger linear correlation with the occurrence rate of PE.The relative risk between BMI and idiopathic PE was（RR=1.08, 95%CI：1.06-1.10,P＆lt;0.01）.The relative risk between BMI and non-idiopathic PE was（RR=1.08,95%CI：1.07-1.10,P＆lt;0.01）.When BMI ≥ 35 kg/m2 ,the risk was increased by 6 times.Conclusion The BMI increase in female patients has significant linear correlation with the occurrence of PE.BMI could be considered as a risk factor for assessing perioperative PE.

关 键 词：手术期间 肺栓塞 体质量指数 女性 肥胖症 

分 类 号：R563.5[医药卫生—呼吸系统]