阴道病原菌感染与胎膜早破的关系及其耐药性分析  

Infectious characteristic analysis and drug-resistance of pathogens among vagina infection pregnancy with premature rupture of membranes

作　　者：楚丽娟[1] 罗婷婷[1] 杨桂林[1] 李秋红[1] 

机构地区：[1]重庆市妇幼保健院检验科,400013

出　　处：《检验医学与临床》2014年第12期1657-1659,共3页Laboratory Medicine and Clinic

基　　金：重庆市卫生局课题(2013-2-133)

摘　　要：目的探讨影响孕妇胎膜早破的具体病原菌及其耐药情况,以合理地指导临床用药。方法随机选取2010年1月至2012年7月该院就诊的感染性胎膜早破的妊娠晚期女性为研究对象（患者组）,未发生胎膜早破的孕妇作为对照（健康对照组）,收集阴道分泌物病原菌,采用肉汤法进行药敏试验。结果患者组病原菌表现为无乳链球菌（b群）和金黄色葡萄球菌检出率高于健康对照组,差异有统计学意义（P〈0.05）。金黄色葡萄球菌对氨苄西林和青霉素完全耐药,对红霉素和克林霉素敏感性分别为33.3%和50%,对四环素为66.7%,对其他抗菌药物均达到83.3%以上。无乳链球菌（b群）对左旋氧氟沙星、阿奇霉素、红霉素和氧氟沙星的敏感性在30%∽40%,但对青霉素类及头孢类抗菌药物敏感率超过80%。结论阴道无乳链球菌（b群）和金黄色葡萄球菌感染对胎膜早破有影响。2种细菌目前药物敏感性控制较好,临床医师应合理使用抗菌药物,避免耐药菌株的产生。Objective The distribution characteristics and antibiotic resistance of specific pathogens among va-gina infection pregnancy with premature rupture of membranes （prom） ,in order to guide rational antibacterial thera-py .Methods During the periods of Jan ,2010 to Jul ,2012 ,pathogens from vagina with infectious pregnancy were gathered ,two groups-prom group and normal control were divided .The drug sensitivity of isolated strains were deter-mined by the broth dilution method .Results Only Streptococcus agalactiae （b group） and Staphylococcus aureus were found statistical significance between the two groups ,presenting higher detection in prom group（P〈0 .05） .The resistant rates of Staphylococcus aureus to penicillin and ampicillin were 100% ,the sensitivity rates to erythrocin and azithromycin were 33 .3% and 50% ,respectively ,to tetracycline were 66 .7% ,others were all above of 83 .3% .The sensitivity rates of Streptococcus agalactiae （b group） to levofloxacin ,azithromycin ,erythrocin ,and ofloxacin were 30% -40% ,yet above 80% of sensitivity to penicillin and cephems .Conclusion Streptococcus agalactiae （b group） and Staphylococcus aureus have an effect on prom .The drug sensitivity to the two bacteria are effected .Rational use of antibiotics and surveillance should be taken into account ,to avoid the development of drug-resistance strains .

关 键 词：胎膜早破 阴道分泌物 孕妇 病原菌 耐药性 

分 类 号：R155.31[医药卫生—营养与食品卫生学]