克塞灵(降纤酶)溶栓治疗急性脑梗死的临床研究  

The Clinical Research of curing acute Cerebral Haemorrhage with Defibrase Solvent

作　　者：王克非 王富贵 

机构地区：[1]辽河油田中心医院神经内科,辽宁盘锦124010

出　　处：《蛇志》2001年第1期30-32,共3页Journal of Snake

摘　　要：目的　探讨克塞灵 (降纤酶 )溶栓治疗急性脑梗死的临床效果及作用机制。　方法　将 1 998年1～ 1 0月收治的 6 8例发病在 72 h内脑梗死患者作为观察组 ,用克塞灵注射剂 1 0 u加入 0 .9%氯化钠注射液2 50 ml中静脉滴注 ,时间大于 1 h,每天 1次 ,连用 6天为 1疗程 ;同期随机采取病情相同的 4 0例脑梗死患者作对照组观察 ,用维脑路通注射剂 0 .4 g加入 0 .9%氯化钠注射液 2 50 ml静脉滴注 ,每天 1次 ,连用 8天。同时两组在用药前后分别观察血液流变学变化。　结果　观察组总有效率 77.94 % ,对照组总有效率52 .50 % ,观察组明显高于对照组。观察组用药后血纤维蛋白原明显降低 ,血粘度得到改善。　结论　克塞灵具有降纤溶栓作用 ,对急性脑梗死患者临床效果较好 ,其主要机理是降低血纤维蛋白原 ,改善血粘度 ,而改善了微循环。该药安全性可靠 ,未见其他部位出血及过敏反应 ,对肝。Objective In order to research clinical efficiency and function of curing acute cerebral haemorrhage with Defibrase Method In 1998,We took the 68 cerebral haemorrhage patients for aobserving group which get disease in 72h,We put 10u Defibrase solvent into 250ml NaCl solvent (0 9NaCl)together,then do intravenous injection,once each day,more than one hour,continue six days for one course,At same time,for the sake of contrast,we tood another 40 cerebral haemorrhage patients for a contrast group,we put 0 4g Venoraton solvent in 250mlNaCl solvent(0 9NaCl)together,then do intravenous injection,once each day,keep 8 days for one course,we observ the change of blood before and after taking medicine Result The efficiency of observing group is 77 94%;The efficiency of contrast group is 52 50%;The patients in observing groups whose fibrinogen in blood is lower,blood viscosity has been improved Conclusion Defibrase solvent has the function of lowering the fibre and dissolving thrombus The clinical efficiency to acute cerebral haemorrhage is better The main principle is to lower the fibre protein in blood ,improve blood viscosity and microcircutation This kind of medicine is safe and reliable,it can't make other body blooding and allergic reaction,and no affect to liver and kidney [

关 键 词：急性脑梗死 克塞灵 纤维蛋白原 降纤酶 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R996.3[医药卫生—临床医学]