固相检测法在肾移植术后抗体监测中的应用  

Antibody monitoring through solid phase assay on renal transplantation

作　　者：曾毅刚[1] 邱建新[1] 

机构地区：[1]上海交通大学附属第一人民医院泌尿外科,上海200080

出　　处：《世界临床药物》2014年第6期351-357,共7页World Clinical Drug

摘　　要：肾移植术前预存的和术后新生成的人类白细胞抗原(HLA)抗体在抗体介导的排斥反应以及慢性移植物肾病中发挥重要作用。采用固相法(SPA)检测HLA抗体,彻底改变了肾移植术后患者免疫状态的监测方式。该法的灵敏度和特异性较高,且测得的HLA抗体在临床上具有重要意义。本文综述SPA在肾移植术后监测中的应用,为临床上肾移植受者的术后随访提供依据。Pre-formed and de novo anti-human leukocyte antigen（HLA） antibodies play an important role in antibody mediated rejection and chronic allograft nephropathy. The solid-phase method totally changed the detection of HLA antibody monitoring of the immune status on renal transplantation recipients. This method has the characteristics of high sensitivity and specificity. HLA antibodies measured by this method have clinical significance. This review summarizes the solid phase assay in the monitoring of renal transplant recipient and provides the basis for clinical follow-up of renal transplant recipients.

关 键 词：肾移植 固相检测法(SPA) 抗体 

分 类 号：R737.11[医药卫生—肿瘤]