脑内P物质在谷氨酸兴奋腹内侧核引起的升压反应中之作用  

ROLE OF SUBSTANCE P IN PRESSOR RESPONSE OF NUCLEUS VENTROMEDIALIS TO GLUTAMATE

作　　者：吴金胜[1] 丁欣[1] 顾蕴辉[1] 王益光[1] 谭璐[1] 

机构地区：[1]北京医科大学生理系,北京100083

出　　处：《中国应用生理学杂志》2001年第1期1-4,共4页Chinese Journal of Applied Physiology

基　　金：卫生部科研基金!(915 0 135 4);国家自然科学基金!(39170 899)资助项目

摘　　要：目的 :分析谷氨酸兴奋下丘脑腹内侧核 (NVM)引起升压反应的机制。方法 :大鼠脑内或静脉注射不同药物 ,记录血压和心率的变化。结果 :①L 谷氨酸 (Glu)兴奋NVM、P物质 (SP)注入背内侧核 (NDM)室旁核 (NPV)或延髓头端腹外侧区 (RVL)均引起升压反应 ;②NVM升压反应可被双侧NDM、NPV或RVL内预先注射 [D Pro2 ,D Phe7,D Trp9] P物质 (SP拮抗剂 )衰减 ,但RVL内注射阿托品无此效应 ;③酚妥拉明 (i v )也能使NVM升压反应减小 ,而心得安或甲基阿托品 (i.v .)对该升压反应无影响。结论 :兴奋NVM可通过NDM (SP受体 ) ,作用于NPV(SP受体 )升压区和RVL(SP受体 ) 交感缩血管神经系统产生升压反应。Aim:To analyze mechanism underlying pressor response of the nucleus ventromedialis(NVM) to glutamate.Methods:Effects of different drugs delivered by intra brain or i.v. injections on blood pressure and heart rate were observed in rats.Results:①Excitation of the NVM by L glutamate(Glu),injection of substance P(SP) into the nucleus dorsomedialis (NDM), nucleus paraventricularis (NPV) or rostral ventrolateral medulla (RVL),all induced pressor responses.②NVM pressor responses could be attenuated by preinjection of [D Pro 2,D Phe 7,D Trp 9] SP (DPDPDT,a substance P antagonist)bilaterally into the NDM,NPV or RVL,but preinjection of atropine into the RVL had no such effect. ③ Phentolamine (i.v.) also reduced the NVM pressor response, but propranolol or methyl atropine (i.v.) had no significant effect.Conclusion: The NVM SPergic neurons can activate NDM SPergic neurons,which proceed to excite the NPV pressor area (SP receptor) and RVL (SP receptor) sympathetic vasoconstrictor nerve system,thereby induce pressor response.The cardiac sympathetic and cardiac vagal nerves are not involved in this response.

关 键 词：腹内侧核 背内侧核 升压反应 P物质 脑 谷氨酸兴奋 

分 类 号：R338.2[医药卫生—人体生理学]