添加谷氨酰胺营养治疗对食管癌患者营养状况影响的meta分析  

Influence of Glutamine Addition on Nutritional Status in Nutritional Therapy of Patients with Esophagus Cancer: a Meta Analysis

作　　者：滑丽美[1] 刘晓军[1] 赵青兰[2] 于建敏[3] 

机构地区：[1]解放军白求恩国际和平医院营养科,石家庄050082 [2]解放军白求恩国际和平医院肿瘤科,石家庄050082 [3]解放军309医院门诊部,北京100091

出　　处：《解放军医药杂志》2014年第6期43-46,53,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的评价添加谷氨酰胺营养治疗对食管癌患者营养状况的影响。方法计算机检索1994—2012年中国知网(CNKI)全文期刊数据库、万方数据库、Pubmed数据库、Cochrane Central Register of Controlled Trials(The Cochrane Library),纳入添加谷氨酰胺营养治疗食管癌患者的随机对照研究,采用RevMan 5.2统计软件进行分析。结果最终纳入的5项研究,包括284例研究对象,其中4项研究属于高质量等级研究。meta分析结果显示,谷氨酰胺组白蛋白、前白蛋白、IgG水平高于常规营养支持组,C反应蛋白水平低于常规营养支持组(P<0.05),两组IgA与IgM水平比较差异无统计学意义(P>0.05)。结论添加谷氨酰胺营养支持治疗可以明显改善食管癌患者营养不良状况,提高免疫力,减少氧化应激损伤,其效果优于常规营养支持。Objective To evaluate the influence of Glutamine addition on nutrition status in nutritional therapy of patients with esophagus cancer. Methods Clinical data of Glutamine addition in nutritional therapy of patients with esophagus cancer was retrieved from electronic database： CNKI,Wanfang Data,Pubmed and Cochrane Central Register of Controlled Trials（ the Cochrane Library） for randomized control trials,and data was analyzed with RevMan 5. 2 software.Results Five study items were recruited including 284 cases and 4 high quality grade studies. Meta analysis results showed that the levels of albumin,prealbumin and IgG were significantly higher,while the C-reactive protein（ CRP） level was significantly lower in Glutamine addition group than those in ordinary nutrition support group（ P〈 0. 05）,but the differences in levels of IgA and IgM were not statistically significant（ P〉 0. 05）. Conclusion Glutamine addition in nutritional therapy of patients with esophagus cancer can significantly improve poor nutritional status,enhance the immunity and reduce damage of the oxidative stress with better effect than that of the ordinary nutrition support.

关 键 词：谷氨酰胺 食管肿瘤 营养疗法 META分析 

分 类 号：R735.1[医药卫生—肿瘤]