伴躯体症状抑郁症患者皮质醇与述情障碍的相关性  

Relationship between the levels of serum cortisol and alexithymia in depressive patients with somatic symptoms

作　　者：卢妍妍[1] 阎琳[1] 蒋珊[1] 李幼辉[1] 

机构地区：[1]郑州大学第一附属医院精神科,郑州450052

出　　处：《中华行为医学与脑科学杂志》2014年第6期511-513,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的 探讨伴躯体症状的抑郁症患者血清皮质醇水平与述情障碍程度的相关性.方法 采用放射免疫法测定30例伴躯体症状的抑郁症患者（躯体组）及30例不伴躯体症状的抑郁症患者（不伴组）晨起血清皮质醇水平,使用述情障碍量表（TAS-20）评定两组患者述情障碍.结果 （1）躯体组血清皮质醇水平显著高于不伴组[（533.88± 144.10） μmol/L vs （458.27±82.87） μmol/L,P＜0.01],差异有统计学意义.（2）躯体组述情障碍总分及识别情感障碍、描述情感障碍因子分高于不伴组[（67.13±6.96）分vs（62.03±7.14）分,（24.50±3.78）分vs （21.63±3.63）分,（15.30±2.69）分vs（13.57±2.03）分,均P＜0.01],差异有统计学意义.（3）躯体组血清皮质醇水平与述情障碍总分正相关（r=0.596,P＜0.01）,与识别情感障碍、描述情感障碍、外向性思维因子分正相关（r=0.391,0.435,0.452,均P＜0.05）.（4）不伴组血清皮质醇水平与述情障碍总分正相关（r=0.418,P＜0.05）,与外向性思维因子分正相关（r=0.489,P＜0.01）.结论 伴躯体症状较不伴躯体症状的抑郁症患者存在较重的述情障碍,具体体现在识别情绪障碍、描述情绪障碍.述情障碍的严重程度与血清皮质醇水平存在正相关关系.Objective To investigate the correlation between the level of serum cortisol and alexithymia in depressive patients with somatic symptoms.Methods The morning level of serum cortisol was measured with radioimmunoassay in 30 depressive patients with somatic symptoms （somatization group） and 30 depressive patients without somatic symptoms （non-somatization group）.The severity of alexithymia was evaluated with Toronto alexithymia Scale（TAS-20）.Results （1） The level of serum cortisol in somatization group was significantly higher than that in non-somatization group（（533.88±144.10） μmol/L vs （458.27±82.87） μmol/L,P〈0.01）.（2） The total TAS score and the factor score of “Difficulty in identifying feelings” and “Difficulty in describing feelings” in somatization group were obviously higher than those in non-somatization group,respectively （（67.13 ± 6.96） vs （62.03±7.14）,（24.50±3.78） vs （21.63±3.63）,（15.30±2.69） vs （13.57±2.03）,all P〈0.01）.（3） The level of serum cortisol in somatization group was positively correlated with the total score of alexithymia （r=0.596,P〈0.01） and the factor score of “Difficulty in identifying feelings”,“ Difficulty in describing feelings”,“ externally oriented thinking”,respectively （r=0.391,0.435,0.452,all P〈0.05）.（4） The level of serum cortisol in non-somatization group was positively related to the total TAS score （r=0.418,P〈0.05） and the factor score of “externally oriented thinking”（r=0.489,P〈0.01）.Conclusions Compared with depressive patients without somatic symptoms,depressive patients with somatic symptoms had more severe alexithymia,especially in “Difficulty in identifying feelings” and “Difficulty in describing feelings”.The severity of alexithymia was positively correlated with the level of serum cortisol.

关 键 词：抑郁症 躯体症状 血清皮质醇 述情障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]