颅内原发性生殖细胞肿瘤162例诊断分析  

Diagnostic analysis of 162 cases of primary intracranial germ cell tumors

作　　者：方陆雄[1] 朱明华[1] 徐书翔[1] 李志勇[1] 漆松涛[1] 

机构地区：[1]南方医科大学南方医院神经外科,广州510515

出　　处：《中华神经外科杂志》2014年第6期541-544,共4页Chinese Journal of Neurosurgery

摘　　要：目的总结颅内原发性生殖细胞肿瘤（GCTs）的临床特性。方法按照2007年WHO CNS肿瘤分类标准，对南方医院神经外科2004年1月至2013年10月收治的162例颅内原发性GCTs的临床资料进行回顾性分析。结果肿瘤呈单病灶135例，多病灶27例，松果体区起源占70．4％、鞍上区20．4％、基底节区7．4％、其他部位1．8％。患者平均年龄14．4岁，松果体区14．5岁，鞍上区14．9岁，基底节区12．6岁。男女之比为7．1：1，松果体区18：1，鞍上区1．4：1，基底节区5：1。全组肿瘤标志物阳性率为42．5％，生殖细胞瘤占46．9％。结论颅内原发性GCTs临床特性明显，仔细分析各种临床资料有助于诊断。及时诊断，合理治疗，50％以上患者可望取得理想结果。Objective To summarize the clinical features of primary intracranial germ cell tumors （GCTs）. Methods Based on the WHO 2007 classification criteria for CNS tumors, we retrospectively analyzed 162 cases of primary intracranial GCTs admitted into Nanfang Hospital from Jan. 2004 to Oct. 2013. Results There were 135 cases of single - focus tumors and 27 multi - focus tumors. 70. 4% of tumors were originated in pineal region, 20.4% in supra - sellar region, 7.4% in basal ganglion region, and 1.8% in other regions. The average age of all cases, pineal region cases, supra - sellar region, and basal ganglion region cases, was 14. 4 years, 14. 5 years, lg. 9 years, and 12. 6 years, respectively. The male/female ratio was 7.1：1 in all cases, and 18：1 in pineal region cases, 1.4：1 in supra - sellar region cases, and 5：1 in basal ganglion region cases. The positive rate of tumor markers was 42. 5%, and germinomas accounted for 46. 9% of all cases. Conclusions The clinical features of GCTs are special, and detailed analysis of clinical data is helpful for the diagnosis. More than a half of patients will achieve ideal therapeutic results through timely diagnosis and reasonable treatment.

关 键 词：中枢神经系统 松果体区 鞍区 基底节区 生殖细胞肿瘤 病理学 

分 类 号：R739.41[医药卫生—肿瘤]