家族性尿道下裂2系5例  

Etiologic analysis of familial Hypospadias

作　　者：李伯全[1] 王增增[1] 崔小健[1] 

机构地区：[1]解放军第254医院泌尿外科,天津300142

出　　处：《中国中西医结合外科杂志》2014年第3期248-250,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探讨诱发家族性尿道下裂的因素和治疗方法。方法:对2系5例家族性尿道下裂患者分别行一期尿道成形术、阴茎腹曲矫正术治疗。结果:5例中2例术后出现尿瘘,分别于术后6个月行尿瘘修补术、4年后行二期带蒂阴囊正中皮瓣尿道成形术,均治愈。结论:家族性尿道下裂基因易感因素发挥着主要作用,手术矫正是有效的治疗方法。Objective To explore the risk factors for hypospadias. Methods Five cases of familial hypo-spadias were retrospectively studied by analyzing the related information of hypospadias phenotype,accompanying other genital malformations,the history of familial hereditary disease family formation,living environment,etc. Results Case 1 and case 2 were first cousins. Case 3 and case 4 were brothers,without other brothers and sis-ters. Case 5 was a cousin of case 3 and case 4,and had only one sister.They had common uncle and aunt,whose familial generation were all females free from deformation.The 5 cases：lived in countryside;without causative fac-tor inducing abnormal growth of urethra;non-consanguineous marriage of grandparent and parents;without family medical history of external deformation;natural gravidity as well as their parents;their parents wre free from relat-ed drug-taking in pregnacy. Conclusion The causative factors of the familial hypospadias are multiple,but the potential effects of genetic susceptibility play the key role.For partial familial hypospadias,the potential ef-fects of genetic susceptibility may be the single and independent factor.

关 键 词：尿道下裂 家族性 病因素 

分 类 号：R699.6[医药卫生—泌尿科学]