Ki-67、PTTG、VEGF与垂体瘤卒中的相关性  

Correlation among Ki-67,PTTG,VEGF and pituitary apoplexy

作　　者：赵华[1] 徐洋洋[2] 鹿向东[3] 徐同江[1] 

机构地区：[1]山东大学附属省立医院神经外科,山东济南250021 [2]山东大学医学院临床医学五年制,山东济南250012 [3]山东省莱芜市人民医院神经外科,山东莱芜271100

出　　处：《山东大学学报（医学版）》2014年第5期82-85,91,共5页Journal of Shandong University:Health Sciences

基　　金：山东省科技发展计划(2010GSF10225);济南市科技发展计划(201303038)

摘　　要：目的探讨Ki-67、PTTG、VEGF在垂体瘤卒中的表达及其意义。方法收集经手术和病理证实的垂体瘤60例,其中垂体瘤卒中组28例,非卒中组32例,分别采用免疫组化法和Western blotting技术检测卒中组及非卒中组垂体腺瘤中的Ki-67、PTTG、VEGF蛋白的表达。结果免疫组化及Western blotting均显示卒中组Ki-67的表达高于非卒中组(P<0.05);卒中组PTTG、VEGF的表达与非卒中组无明显差异(P>0.05)。结论垂体瘤卒中的细胞增殖活性明显高于非卒中的垂体瘤的细胞增殖活性,而PTTG、VEGF在垂体瘤卒中及非卒中中诱生血管的能力相同。Objective To explore the expressions and significance of Ki-67,PTTG and VEGF in pituitary apoplexy. Methods A total of 60 cases of pituitary adenoma,including 28 cases of apoplexy adenoma（apoplexy group） and 32 cases of non-apoplexy pituitary adenoma（non-apoplexy group） were collected. Expressions of Ki-67,PTTG and VEGF were analyzed with immunohistochemical method and Western blotting. Results The Ki-67 expression was significantly higher in the apoplexy group than in the non-apoplexy group（P ＆lt; 0. 05）; however,there was no significant difference in the PTTG and VEGF expressions between the two groups（P ＆gt; 0. 05）. Conclusion Cell proliferation in pituitary apoplexy is significantly higher than in non-apoplexy pituitary,while PTTG and VEGF have the same ability to induce the blood vessel.

关 键 词：垂体瘤卒中 细胞增殖周期核抗原 垂体瘤转化基因 血管内皮生长因子 免疫组化 蛋白质印迹法 

分 类 号：R736.4[医药卫生—肿瘤]