磁液双悬浮离心血泵左心辅助的动物实验  

In vivo evaluation of magnetic and hydrodynamic suspension centrifugal ventricular assist device

作　　者：张杰民[1] 刘晓程[2] 刘志刚[2] 李翼鹏 韩志富 许剑 荣彦生[4] 刘天文[1] 张嵬[2] 姜洋 李雪 王伟 王洪武[4] 贾克刚[5] 刘雯 高航 张磊 

机构地区：[1]天津泰达国际心血管病医院辅助循环研究室, 300457 [2]天津泰达国际心血管病医院心脏外科,300457 [3] 中国运载火箭研究院第十八研究所 [4]天津泰达国际心血管病医院麻醉科, 300457 [5]天津泰达国际心血管病医院检验科,300457

出　　处：《中华医学杂志》2014年第22期1740-1743,共4页National Medical Journal of China

基　　金：基金项目：天津市科委重大科技支撑基金（09ZCKFSF01100）

摘　　要：目的：检测左心辅助羊应用磁液双悬浮离心血泵和控制器的各项性能。方法在全麻、非体外循环、心脏跳动下，将血泵流出端人工血管吻合于降主动脉，左心尖植入血泵流入端，建立左心辅助实验模型，记录术前术后血液、生化和血泵的各项指标。共完成11只左心辅助羊的动物实验。结果11只左心辅助羊，心室颤动死亡3例，急性肺水肿死亡1例；左室血栓及左室碎肉至血泵停止工作5例；1例血泵左心辅助59 h，因血泵电流逐渐增高人为停泵，羊存活75 d，死于感染；1例术后应用华法林抗凝，血泵正常工作，辅助流量3.0～3.4 L/min，血液、生化及尿液各项指标基本正常，游离血红蛋白3.3～44.3 mg/L，可携带控制器和锂电池自由行走。因血泵流入管道向左室前壁移位损伤室壁，致心肌组织入泵，血泵停止转动，辅助羊健康存活120 d。分解血泵未见血栓。结论磁液双悬浮血泵和控制器性能良好，辅助满意，各项生理指标基本正常，初步达到了临床前应用水平。Objective To verify the function of magnetic and hydrodynamic suspension centrifugal ventricular assist device in a sheep model .Methods The device was implanted into left ventricular apex on beating hearts.The outflow graft of each device was anastomosed to descending aorta in 11 animals. Hematologic , biochemical and blood clotting tests before and after surgery were performed .The data of pump functions were collected continuously .Results Among them, there were death from ventricular fibrillation （n=3）, acute pulmonary edema （n=1） and left ventricular thrombus and molar cardiac muscle （n=5）. One animal survived for 75 days and died from bacterial infection after pumping for 59 hours.During assistance for 120 days, the flow rate was 3.0 -3.4 L/min.All hematologic and biochemical parameters were within normal ranges in one sheep .The walking sheep wore the controller and lithium battery with a blood pump.Neither mechanical wearing nor thrombus formation was observed for inflow and outflow conduits or pump interior .Conclusions The magnetic and hydrodynamic suspension centrifugal ventricular assist device demonstrates excellent hemocompatibility and reliability .And there is a great prospect of clinical success .

关 键 词：心脏辅助装置 心力衰竭 磁液悬浮离心血泵 游离血红蛋白 

分 类 号：R-332[医药卫生]