1-(3-吡啶甲酰基)-4-芳酰氨基硫脲类化合物的合成  

Synthesis and Study on the 1-pyridinoyl-4-aroylthiosemicarbazides

作　　者：赵青[1] 王亚平[2] 王兴国[1] 

机构地区：[1]兰州大学化学化工学院,甘肃兰州730000 [2]北京天衡药物研究院,北京100071

出　　处：《兰州大学学报（自然科学版）》2001年第1期47-50,共4页Journal of Lanzhou University(Natural Sciences)

摘　　要：报道了 1 - (3-吡啶甲酰基 ) - 4 -芳酰氨基硫脲类化合物的合成及鉴定 .以烟酸和取代苯甲酸为起始原料 ,合成了一系列分子中含吡啶基团的芳酰氨基硫脲 ,经元素分析 ,IR光谱 ,1 H NMR谱和 MS谱分析 ,确定了这类化合物的结构 .The synthesis and study on the 1 pyridinoyl 4 aroylthiosemicabazides are reported minutely. The synthesis of 1 pyridinoyl 4 aroylthiosemicarbazides was achieved by esterification, acylation and addition reaction, with nicotinic acid and substituted compounds of benzoic acid as starting materials. The compound structures were confirmed by elemental analysis, IR, 1H NMR and MS.

关 键 词：芳酰基异硫氰酸酯 1-(3-吡啶甲酰基)-4-芳氨基 硫脲类化合物 

分 类 号：R914.5[医药卫生—药物化学] O626[医药卫生—药学]