甲磺酸托烷司琼在子宫颈癌手术后止吐作用的临床观察  

Clinical observation of tropisetron mesylate in the prevention of nausea and vomiting after cervical cancer surgery

作　　者：刘文粤 

机构地区：[1]粤北人民医院麻醉科,广东韶关512026

出　　处：《临床医学》2014年第6期18-19,共2页Clinical Medicine

摘　　要：目的观察甲磺酸托烷司琼在子宫颈癌手术后恶心呕吐(postoperative nausea and vomiting,PONV)的防治效果。方法选择择期妇科子宫颈癌手术患者70例,随机分为治疗组和对照组,每组35例。两组均采用气管内插管全麻,治疗组患者术毕给予甲磺酸托烷司琼6 mg静脉注射。术后48 h内观察并评估PONV发生率及程度,记录需要止吐治疗的患者例数。结果治疗组术后PONV的发生率为20%;对照组为71%,差异有统计学意义(P<0.05)。结论术毕静脉注射甲磺酸托烷司琼可有效预防子宫颈癌手术后恶心呕吐的发生。Objective To observe the preventive effects of tropisetron mesylate on postoperative nausea and vomiting（PONV） in cervical cancer surgery. Methods Seventy patients with cervical cancer scheduled for operation were randomly divided into treatment group and control group,with 35 cases in each groups. The patients in the two groups were all given general anesthesia with endotracheal intubation,and the patients in treatment group were intravenously given 6 mg tropisetron mesylatei at the end of surgery. The incidence and degree of PONV within the first 48 hours after operation was observed and evaluated. The number of patients,who received metoclopramide for PONV,was also recorded. Results The incidence of postoperative PONV was 20% in the treatment group and 71% in the control group,there was significant difference between the two groups（P 〈 0. 05）. Conclu-sion At the end of cervical cancer surgery,intravenous injection of tropisetron mesylate can effectively prevent PONV.

关 键 词：子宫颈癌手术 恶心呕吐 甲磺酸托烷司琼 

分 类 号：R737.33[医药卫生—肿瘤]