JAK/STAT3信号通路及其在胃肠道疾病中作用的研究进展  

Advances in Study on JAK/STAT3 Signaling Pathway and its Role in Gastrointestinal Diseases

作　　者：薛翔[1] 聂时南[1] 

机构地区：[1]南京军区南京总医院急救医学科,210002

出　　处：《胃肠病学》2014年第5期301-304,共4页Chinese Journal of Gastroenterology

基　　金：中国人民解放军南京军区重大专项课题(No.12Z32)

摘　　要：JAK/STAT3信号通路广泛存在于机体各个组织中,介导细胞增殖、分化、迁移、凋亡、免疫调节等多种生物学过程。近年研究发现该通路激活在胃肠道疾病中起重要作用,可促进胃癌、结直肠癌生长和肿瘤血管生成,并抑制肿瘤细胞凋亡,同时参与炎症性肠病的发生。针对JAK/STAT3信号通路的抑制剂在一些疾病模型中显示出良好的疗效。本文就相关研究进展作一综述。JAK/STAT3 signaling pathway exists in various organs and tissues and mediates multiple biological processes including cell proliferation,differentiation,migration,apoptosis and immunoregulation.Recently,it has been revealed that this pathway plays an important role in gastrointestinal diseases,promoting tumor growth,angiogenesis and inhibiting apoptosis in gastric and colorectal cancers,and being implicated in the pathogenesis of inflammatory bowel disease.Inhibitors targeting JAK/STAT3 pathway showed promising outcome in some disease models.In this review article,the advances in study of abovementioned issues were summarized.

关 键 词：JAK STAT3 信号通路 胃肠疾病 胃肿瘤 结直肠肿瘤 炎症性肠病 

分 类 号：R57[医药卫生—消化系统]