少突胶质细胞瘤中Wnt5a的表达及意义  

Expression of Wnt5a and its clinical significance in human oligodendroglial tumors

作　　者：卜海激[1] 王毛毛[2] 

机构地区：[1]上海解放军第455医院病理科,上海200052 [2]上海解放军第411医院神经外科,上海200081

出　　处：《临床与实验病理学杂志》2014年第6期629-632,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨Wnt5a蛋白在少突胶质细胞瘤中的表达及其临床意义。方法利用组织芯片技术及免疫组化SP法检测Wnt5a在69例少突胶质细胞瘤组织和28例肿瘤旁脑组织中的表达,分析其表达与少突胶质细胞瘤的临床病理参数的关系,并对43例有随访资料的少突胶质细胞瘤患者Wnt5a进行分析。结果 69例少突胶质细胞瘤中Wnt5a的阳性率为82.6%(57/69),肿瘤周围脑组织中Wnt5a的阳性率为46.2%(13/28),二者差异有统计学意义(P<0.05);Wnt5a在少突胶质细胞瘤中的表达与患者性别、年龄、肿瘤部位、组织学分级、大小等均无明显关系(P均>0.05);43例有随访资料的病例中,Wnt5a阳性病例的局部复发率(76.5%,26/34)明显高于Wnt5a阴性病例的局部复发率(33.3%,3/9)(P<0.05)。Kaplan-Meier生存分析显示Wnt5a蛋白阳性患者中位生存期(45.38个月)低于Wnt5a阴性患者(51.67个月),差异无统计学意义(P>0.05)。结论 Wnt5a可能在少突胶质细胞瘤的发生、发展中起重要作用。Purpose To investigate the expression of WntSa in human oligodendroglial tumors and its clinical significance. Methods The expression of WntSa in oligodendroglial tumors and paracancerous brain tissues was examined by tissue microarrays and immunohistochemical staining. 43 patients were followed up after operation. Results The expression of WntSa in oligodendroglial tumors and normal brain tissues was 82. 6% （57/69） and 46.2% （13/28） （P 〈0. 05）, respectively. The recurrent rates of positive expression tumor for WntSa were 76. 5% （26/34）, which was significantly higher than those with negative expression （33.3%, 3/9） （P 〈 0. 05 ）. These was no significant correlations between the expression of WntSa and gender, age, tumor location, size and tumor differentiation （P 〉 0.05 ）. Additionally, the patients with positive tumors had a slightly lower median cancer-specific survival than those with negative WntSa expression （45.38 vs 51.67 months）. However, the difference was not statistically significant （P 〉 0. 05）. Conclusion WntSa may play an important role in the pathogenesis and progression of oligodendroglial tumors.

关 键 词：少突胶质细胞瘤 组织芯片 WNT5A 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]