前列腺癌中VEGF-C蛋白的表达及意义  

Expression of VEGF-C protein and its clinical significance in prostate cancers

作　　者：张秀梅 顾金松 刘曙 石明 苏建军 

机构地区：[1]江苏省兴化市人民医院病理科,兴化225700

出　　处：《临床与实验病理学杂志》2014年第6期646-648,652,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的观察VEGF-C蛋白在前列腺癌(prostate cancer,PCa)组织中的表达及与临床病理参数的关系。方法应用免疫组化法检测VEGF-C在78例PCa组织、21例良性前列腺增生(benign prostate hyperplasia,BPH)组织中的表达,并分析其表达水平与PCa临床病理参数及预后的关系。结果 VEGF-C蛋白在PCa组织中的阳性率(71.7%,56/78)明显高于BPH组织(0,0/21),差异有统计学意义(P<0.001),VEGF-C蛋白在PCa中表达与高Gleason评分(P=0.007)、高临床T分期(P<0.001)、淋巴结转移(P<0.001)有关,与总体生存率具有相关性(P=0.012)。结论 VEGF-C在PCa的发生、发展中可能发挥促进作用,与PCa的发生、分化和淋巴结转移有一定的关系,有可能成为判断PCa预后的新标志和基因治疗的新靶点。Purpose To detect the expression of VEGF-C protein in prostate cancers （PCa） tissues and to explore its correlation with clinicopathological parameters. Methods Immunohistochemistry was used to detect VEGF-C protein in 78 cases of PCa, 21 cases of benign prostatic hyperplasia tissues and to analyze the relationship between the expression levels and clinicopathologieal parameters as well as prognosis. Results The positive rate of VEGF-C protein in PCa tissues （71.7% , 56/78） was significantly higher than benign prostatic hyperplasia （0, 0/21 ） （P 〈0. 001 ）. Increased expression of VEGF-C protein was more often detected in PCa with high Gleason score （ P = 0. 007 ）, advanced T stage （P 〈 0. 001 ）, lymph node metastasis （ P 〈0. 001 ） and overall survival （ P = 0. 012 ）. Conclusion Our data indicate that VEGF-C may play a catalytic role in carcinogenesis and progression of PCa. The expression of VEGF-C protein has a certain relationship with an early event in tumorigenesis, differentiation and lymph node metastasis and may become a potentially useful target for prognostic and therapeutic application in PCa.

关 键 词：前列腺肿瘤 VEGF-C 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]