炎症性肠病74例肺功能测定的临床评价  

Clinical evaluation of lung function in 74 patients with inflammatory bowel disease

作　　者：赵玉洁[1] 夏玉敬[1] 刘占举[1] 

机构地区：[1]同济大学附属第十人民医院消化内科,上海200072

出　　处：《中华消化杂志》2014年第6期379-383,共5页Chinese Journal of Digestion

摘　　要：目的 对IBD患者的肺功能进行测试及评估,探究IBD合并肺功能异常的相关性及特点.方法 收集2012年1月至2013年6月住院治疗的IBD患者74例,其中UC 34例、CD 40例,以及同时期健康体检者74名作为对照.建立病史资料库,并按一般情况、生物化学指标、肺功能指标、胸部X线、诊断和治疗情况等分别进行统计学处理.计量资料组间比较采用t检验,计数资料组间比较采用卡方检验,等级资料组间比较采用秩和检验,多因素相关分析采用Logistic回归.结果 74例IBD患者中,出现肺功能异常的共56例（75.68％）,IBD组、CD组的残气异常患者比例[51.35％（38/74）和60.00％（24/40）]均显著高于对照组[31.08％（23/74）],差异有统计学意义（t=-2.557,P=0.013; t=2.236,P=0.031）,UC组和CD组之间差异无统计学意义（P＞0.05）.肺功能异常与IBD病变程度（F=0.744,P=0.690）、病变范围（F=2.796,P=0.424）无明显相关.病程≥5年为可能的保护性因素（OR=0.824,95％ CI：0.687～0.987）,ESR升高为可能的危险因素（OR=1.093,95％CI：0.994～1.202）.结论 IBD患者多数合并肺功能减退,无论何种病变程度或病变范围均有可能发生,病程和ESR可能是合并肺功能异常的影响因素.Objective To test and evaluate the lung function of patients with inflammatory bowel disease （IBD）,and to explore the correlation and characteristics between IBD and abnormal lung function.Methods From January 2012 to June 2013,74 hospitalized patients with IBD were collected,among them 34 cases were ulcerative colitis （UC） and 40 cases were Crohn＇s disease （CD）.At the same period,74 healthy individuals were enrolled as controls.The database of history was established.The general state,chemical examinations,lung function,chest X-ray,the diagnosis and treatment were statistically analyzed separately.T test was performed for comparison between groups of measurement data,chi square test was for comparison between groups of count data,rank-sum test was for comparison between groups of ordinal data,and Logistic regression was for multivariate analysis.Results Among the 74 patients with IBD,56 patients （75.68％） were found with abnormal lung function.The percentage of abnormal residual volume of IBD and CD group was 51.35％（38/74） and 60.00％（24/40）,which were higher than that of control group [31.08％ （23/74）] and the differences were statistically significant （t=-2.557,P=0.013; t=2.236,P=0.031）.There were no significant difference between UC and CD group （P＞0.05）.There was no significant correlation between abnormal pulmonary function and the severity of IBD （F=0.744,P=0.690） or extent of lesion （F-2.796,P=0.424）.The course of disease ≥five years was a possible protecitive actor （OR=0.824,95％CI：0.687-0.987）,and elevated erythrocyte sedimentation rate （ESR） was a possible risk factor （OR=1.093,95％CI：0.994-1.202）.Conclusions Most IBD patients are complicated with impaired lung function.It might occur regardless of severity or extent of disease.Course of the disease and ESR may he the influence factors in abnormal lung function.

关 键 词：炎症性肠病 结肠炎 溃疡性 CROHN病 肺功能 

分 类 号：R574[医药卫生—消化系统]