Prdm1在哺乳动物胚胎和生殖细胞发育中的作用  

Prdm1 Functions in Mammalian Embryonic and Germ Cell Development

作　　者：李娜[1] 吴江[1] 华进联[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西省干细胞工程技术研究中心,杨凌712100

出　　处：《中国细胞生物学学报》2014年第6期826-831,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31272518);教育部博士点基金(批准号:RFDP;20120204110030)资助的课题~~

摘　　要：Prdm1(PR domain zinc fi nger protein 1),又称为Blimp1(B-lymphocyte-induced maturation protein-1),是一个具有锌指结构的转录因子,通过调控多个基因的表达影响哺乳动物多种类型细胞的发育分化。从1991年发现至今,有关Prdm1的研究进展迅速,Prdm1在促进B细胞向浆细胞终末分化过程中的作用已经得到共识。但是,在小鼠及其他哺乳动物的胚胎发育过程中,尤其是关于Prdm1在生殖细胞发育分化中的作用机理研究则起步相对较晚。近期发现,在哺乳动物胚胎发育过程中,Prdm1在原始生殖细胞的形成、干细胞全能性的维持以及其他组织器官的形成中都发挥了重要的作用。Prdml （PR domain zinc finger protein 1）, also known as Blimpl （B-lymphocyte-induced matu- ration protein-1）, is a transcriptional factor with a zinc-finger domain. It regulates the differentiation of multiple cell types by affecting the expression of relevant genes. Since reported in 1991, its function in regulating the terminal differentiation of B cells into plasma cells has been extensively studied. However, the function of Prdml in embry- onic development of mice and other animals has not been well understood, specifically in germ cell development and differentiation. Recently, it has been demonstrated that Prdml had an important role in the formation of primordial germ cell （PGC）, the maintenance of stem cell characteristic, and the formation of multiple tissues and organs during embryo development.

关 键 词：PRDM1 胚胎发育 生殖细胞 哺乳动物 

分 类 号：Q954.4[生物学—动物学]