D-CIK治疗降低外周血EMT相关分子表达的初步研究  

D-CIK therapy to reduce the expression of Twist and Vimentin mRNA in circulating colorectal cancer cells

作　　者：马磊[1] 金川[1] 邓旭斌[1] 陆勤[1] 刘晓燕[1] 陈文晟[1] 邹青峰[1] 

机构地区：[1]广州医科大学附属肿瘤医院 广州医科大学肿瘤研究所,510090

出　　处：《国际医药卫生导报》2014年第14期2030-2033,共4页International Medicine and Health Guidance News

基　　金：广东省科技厅科研项目（20118080701021）;广州医学院科研项目（2013C61）

摘　　要：目的 探讨D-CIK治疗结肠癌后,患者外周血中EMT相关分子的变化情况及意义.方法 本研究纳入34例明确诊断为结肠癌患者,接受D-CIK细胞回输治疗,观察检测治疗前后患者外周血中EMT相关分子变化情况及治疗过程中相关不良反应.结果 患者接受D-CIK治疗后,循环血中EMT相关分子出现了明显的变化,和治疗前对比,Twist和Vimentin的表达水平明显下降（P＜0.05）.治疗过程中未见严重的不良反应.结论 D-CIK治疗安全可靠,可以减少患者外周血中EMT相关分子的表达.Objective To investigate the significance of change of EMT-associated proteins in colon cancer patients treated with D-CIK.Methods The study included 34 cases of advanced colon cancer undergoing D-CIK treatment.The EMT-associated molecules in peripheral blood were detected before and after treatment.Treatment-related adverse reactions were also observed during treatment progress.Result D-CIK treatment reduced the expression of Twist and Vimentin in peripheral blood of colon cancer patients,and no significant adverse reactions were observed.Conclusion D-CIK treatment can reduce the expression of Twist and Vimentin mRNA in circulating colorectal cancer cells.

关 键 词：结肠癌 循环肿瘤细胞 表皮间质转化 

分 类 号：R735.35[医药卫生—肿瘤]