铝镁加混悬液联用埃索美拉唑治疗幽门螺杆菌阳性十二指肠溃疡的疗效观察  

Almagate suspension in combination with esomeprazole for duodenal ulcer patients positive in Helicobacter pylori

作　　者：关瑞云[1] 廖朝峰[1] 

机构地区：[1]深圳市第八人民医院药学部,518101

出　　处：《国际医药卫生导报》2014年第14期2134-2136,共3页International Medicine and Health Guidance News

摘　　要：目的 观察铝镁加混悬液联用埃索美拉唑治疗幽门螺杆菌阳性十二指肠溃疡的临床疗效.方法 将幽门螺杆菌感染阳性的十二指肠溃疡患者124例随机分为两组：对照组用埃索美拉唑＋阿莫西林＋克拉霉素抗Hp治疗,7天后单用埃索美拉唑;治疗组用埃索美拉唑＋阿莫西林＋克拉霉素抗Hp治疗,7天后应用埃索美拉唑联合铝镁加混悬液;治疗4周后复查胃镜,观察十二指肠溃疡愈合情况,停药4周后复查14C呼气试验,比较两组患者溃疡愈合率、治疗有效率及Hp根除率.结果 对照组和治疗组溃疡愈合率分别为61.29％和66.13％,差异无统计学意义（P＞0.05）;对照组和治疗组溃疡有效率分别为82.26％和95.16％,差异有统计学意义（x 2=5.153,P＜0.05）;对照组和治疗组Hp清除率分别为82.26％和79.03％,差异无统计学意义（P＞0.05）.结论 铝镁加混悬液联用埃索美拉唑治疗幽门螺杆菌阳性十二指肠溃疡的疗效优于单用埃索美拉唑.Objective To observe the effect of almagate suspension in combination with esomeprazole for duodenal ulcer patients positive in Helicobacter pylori.Methods 124 duodenal ulcer patients positive in Helicobacter pylori were randomized into two groups.The control group was given esomeprazole alone after 7-day＆#39;s anti-H.pylori triple therapy including esomeprazole,amoxicillin,and clarithromycin.The treatment group was treated with the same therapy plus almagate suspension.Four weeks after the treatment.both groups returned to recheck the duodenal ulcer healing by gastroscope.14C-urea breath test was （rechek） four weeks after the end of the treatment.The ulcer healing rates,total effective rates,and H.pylori eradication rates were compared between the two groups.Results There was no statistical difference in the duodenal ulcer healing rate between these two groups （61.29% vs.66.13%,P 〉 0.05）.There was statistical difference in the duodenal ulcer total effective rate between these two groups （82.26% vs.95.16%,x 2=5.153,P 〈 0.05）.There was no statistical difference in the duodenal ulcer H.pylori eradication rate between these two groups （82.26% vs.79.03%,P 〉 0.05）.Conclusions Almagate suspension in combination with esomeprazole is a more effective therapy method for duodenal ulcer patients positive in Helicobacter pylori than esomeprazole alone.

关 键 词：十二指肠溃疡 幽门螺旋杆菌 铝镁加混悬液 埃索美拉唑 

分 类 号：R573.1[医药卫生—消化系统]