右佐匹克隆联合盐酸氟西汀治疗脑卒中后抑郁的疗效分析  

Analysis of the Efficacy of Eszopiclone Combined with Fluoxetine Hydrochloride for the Treat-ment of Post-stroke Depression

作　　者：薛良[1] 

机构地区：[1]上海市宝山区高境镇社区卫生服务中心药剂科,上海200435

出　　处：《医学临床研究》2014年第5期905-907,共3页Journal of Clinical Research

摘　　要：【目的】观察分析右佐匹克隆联合盐酸氟西汀治疗脑卒中后抑郁的临床疗效。【方法】选择本院自2009年12月至2013年10月收治入院的脑卒中后并发抑郁症（PSD）的患者74例，按用药方法为治疗组39例和对照组35例。治疗组给予右佐匹克隆合用抗抑郁药物盐酸氟西汀，对照组则单用氟西汀，连续服用6周。采用汉密尔顿抑郁量表（HAMD）、神经功能缺损评分表（NIHSS）和睡眠障碍量表（SDRS）评价疗效，副反应量表（TESS）评价不良反应。治疗前和治疗第2、4、6周后各评定一次。【结果】治疗组和对照组治疗后的HAMD、NIHSS和 SDRS评分较治疗前均有显著的下降（P＜0．05）；治疗组 HAMD和 NIHSS评分在治疗2周后的改善程度优于对照组，其差异具有统计学意义（P ＜0．05）；SDRS评分在各时点组间比较的差异均无统计学意义（P＞0．05）；治疗组总有效率优于对照组的总有效率（94．9％ vs 80．0％），其差异有统计学意义（P＜0．05）；两组不良反应发生率的差异无统计学意义（P＞0．05）。【结论】右佐匹克隆联合盐酸氟西汀治疗PSD疗效明显，见效快，耐受性较好，值得在临床上推广运用。[Objective]To observe and analyze clinical efficacy of eszopiclone combined with fluoxetine hydrochloride for the treatment of post-stroke depression（PSD）.[Methods]A total of 74 patients with PSD in our hospital from Dec.2009 to Oct.2013 were randomly divided into treatment group（n=39）and control group（n=35）.The treatment group received eszopiclone combined with fluoxetine hydrochloride,while the control group was given antidepressive drug fluoxetine hydrochloride alone for continuous 6 weeks.The effica-cy was evaluated by using Hamilton depression scale（HAMD）,national institute of health stroke scale（NIH-SS）and sleep dysfunction rating scale（SDRS）.Treatment emergent symptom scale（TESS）was adopted to as-sess side effects.The assessment was performed before and 2,4 and 6 weeks after treatment.[Results]Com-pared with before treatment,the scores of HAMD,NIHSS and SDRS were decreased in both two groups after treatment（P0.05）.The total effective rate of treat-ment group was 94.9%,which was better than the control group（80.0%）.There was no significant differ-ence in the incidence of adverse reaction（P 〉0.05）.[Conclusion]Eszopiclone combined with fluoxetine hydrochloride for the treatment of PSD has obvious efficacy,rapid effect and good tolerance to adverse reac-tion.Therefore,it is worthy of clinical promotion.

关 键 词：卒中 并发症 抑郁症 药物疗法 氟西汀 投药和剂量 

分 类 号：R743[医药卫生—神经病学与精神病学]