前列腺穿刺活检患者中血清高敏C反应蛋白测定的临床意义  

Clinical significance of serum high sensitive C-reactive protein in patients undergone prostate biopsy

作　　者：莫晓东[1] 蔡晓峰[2] 李纲[1] 张学锋[1] 唐敬[1] 浦金贤[1] 侯建全[1] 

机构地区：[1] 苏州大学附属第一医院泌尿外科,215006 [2] 苏州大学附属第一医院超声科,215006

出　　处：《中华泌尿外科杂志》2014年第6期461-464,共4页Chinese Journal of Urology

基　　金：江苏省医学重点人才基金（Rc2011108）;江苏省医学重点学科基金（XK201151）

摘　　要：目的 探讨血清高敏C反应蛋白（hs-CRP）在前列腺穿刺活检患者中的临床意义.方法 测定273例经直肠前列腺穿刺活检患者的hs-CRP水平.年龄44～ 95岁,平均69岁.病理诊断为前列腺癌（PCa） 96例,良性前列腺增生（BPH） 177例.比较PCa和BPH患者hs-CRP的差异,以及hs-CRP增高和正常者的前列腺穿刺阳性率.采用Logistic回归法分析hs-CRP、总PSA（tPSA）、PSA密度（PSAD）、前列腺总体积（TPV）和年龄等因素对前列腺穿刺阳性率的影响. 结果 PCa患者血清hs-CRP的中位数（上四分位数～下四分位数）为3.22 mg/L（1.22～9.84 mg/L）,BPH患者为1.24 mg/L（0.55～2.76 mg/L）,差异有统计学意义（P＜0.05）.hs-CRP＞3 mg/L和≤3 mg/L患者的前列腺穿刺阳性率分别为55％（51/92）和25％（45/181）,差异有统计学意义（P＜0.05）.Logistic回归分析结果显示,hs-CRP、tPSA、TPV和年龄是影响前列腺穿刺阳性率的独立因素,hs-CRP的OR值高于tPSA、TPV和年龄. 结论 hs-CRP升高时前列腺穿刺活检的PCa检出率增加.hs-CRP是影响前列腺穿刺活检阳性率的独立因素.Objective To assess the clinical significance of serum high sensitive C-reactive protein （hs-CRP） in patients undergone prostate biopsy.Methods A total of 273 consecutive patients were enrolled,aged 44-95 years （mean,69 years）.All the patients underwent prostate biopsy.The pathological findings showed 96 cases with prostate cancer （PCa） and 177 cases with benign prostate hyperplasia （BPH）.The difference of hs-CRP level between patients with PCa and those with BPH was analyzed.The positive prostate biopsy rate was compared between the patients with high hs-CRP level and those with normal hs-CRP level.Logistic regression was used to evaluate the effect of factors such as hs-CRP,tPSA,PSA density,prostate volume and age on prostate biopsy.Results The medians （interquartile range） of hs-CRP were 3.22 mg/L （1.22-9.84 mg/L） in patients with PCa and 1.24 mg/L （0.55-2.76 mg/L） in those with BPH,respectively,with significant difference（P〈0.05）.The positive prostate biopsy rate in patients with high hs-CRP （〉 3 mg/L）was 55% （51/92）,higher than that in those with normal hs-CRP （≤ 3 mg/L）.The odds ratio of hs-CRP was larger than that of all other factors analyzed including tPSA,prostate volume and age according to the Logistic regression analysis.Conclusions Elevated serum hs-CRP level is associated with increased positive prostate biopsy.Serum hs-CRP acts as an independent factor increasing the positive prostate biopsy rate in patients undergone prostate biopsy.

关 键 词：高敏C反应蛋白 前列腺肿瘤 前列腺增生 前列腺穿刺 

分 类 号：R737.25[医药卫生—肿瘤]