多奈哌齐联合疏血通治疗老年性痴呆的疗效分析  

Clinical effect analysis of donepezil combined with Shuxuetong in the treatment of senile dementia

作　　者：廖开成 潘文览 

机构地区：[1]广东惠州市中大惠亚医院神经科,516081 [2]惠州市大亚湾区人民医院内科

出　　处：《中国实用医药》2014年第16期15-17,共3页China Practical Medicine

摘　　要：目的探讨老年性痴呆患者在联合服用多奈哌齐和疏血通后对认知和行为功能的临床疗效。方法把本院抽取的100例老年性痴呆患者随机平均分为两组,分别是对照组50例和试验组50例,对照组患者给予丹参注射液,试验组患者在服用多奈哌齐的同时,给予注射疏血通。观察并比较两组患者12个月后的简易智力状态检查量表(MMSE)评价和日常生活功能量表(ADL)评价,进行疗效统计。结果 12个月后试验组的患者MMSL评分明显高于治疗前,ADL评分明显低于治疗前,与对照组相比改善比较明显,且试验组患者的治愈有效率为83.0%,明显高于对照组的65.0%,P<0.05,差异具有统计学意义。结论老年性痴呆患者在同时给予多奈哌齐和疏血通治疗后,治疗效果、认知和行为功能明显得到改善,临床效果好于单用丹参注射液。Objective To explore the clinical curative effect of donepezil combined with Shuxuetong on cognitive and behavioral function of senile dementia. Methods The hospital sample of 100 patients with senile dementia were randomly divided into two groups, control group（50 cases） and experimental group（50 cases）, control group were treated with Danshen injection, the patients took donepezil and at the same time, given an injection of Shuxuetong injection. The two groups were observed and compared after 12 months of Mini Mental State Examination （MMSE） scale evaluation function and activities of daily living scale （ADL） assessment of curative effect, the statistical. Results After 12 months test group MMSL scores were significantly higher than before treatment, ADL score was significantly lower than that before treatment, compared with control group improved significantly, and the cure of test group efficiency（83%） was significantly higher than that of the control group（65%）, P〈0.05, with statistical significance. Conclusion Senile dementia patients treated with donepezil and Shuxuetong treatment, treatment effect at the same time, cognitive and behavioral function are improved, clinical effect is better than single use of salvia miltiorrhiza injection.

关 键 词：老年性痴呆 多奈哌齐 疏血通 疗效 

分 类 号：R749.16[医药卫生—神经病学与精神病学]