正交试验优选复方酮康唑凝胶剂的基质配比  

Optimization of Base Ratio for Compound Ketoconazole Gels by Orthogonal Experimental Design

作　　者：杨盼鑫[1] 黄文涛[1] 

机构地区：[1]武汉市中西医结合医院药学部制剂中心,武汉430022

出　　处：《中国药师》2014年第6期958-961,共4页China Pharmacist

基　　金：武汉市卫生局课题(编号:WX13D01)

摘　　要：目的:优选复方酮康唑凝胶剂的最佳基质配比。方法:通过正交试验设计,利用溶解扩散模型筛选出最佳基质配比,并以HPLC法同时测定酮康唑和硝酸咪康唑的含量。结果:最佳凝胶基质配比为卡波姆-940 0.3%、甘油30%、聚乙二醇400 10%。结论:凝胶基质配比合理,凝胶中酮康唑和硝酸咪康唑的单位面积累计渗透量均值同为最大值。Objective：To select the optimal base ratio for compound ketoconazole gels.Methods：Using orthogonal experimental design,the optimal base ratio was screened by solution-diffusion model,and two components （ketoconazole and miconazole nitrate） in the gels were simultaneously determined by HPLC.Results：The optimal base ratio was 0.3% carbomer-940,30% glycerol and 10%polyethylene glycol 400.Conclusion：The established formula is reasonable,and the average accumulative permeation per unit area of both ketoconazole and miconazole nitrate reaches maximum in the gels.

关 键 词：正交试验设计 酮康唑 硝酸咪康唑 凝胶剂 

分 类 号：R978.5[医药卫生—药品]