小胶质细胞在酒精性脑损伤中的作用  

Effect of microglia in alcohol-induced brain damage

作　　者：李锦程[1] 赵海苹[1] 罗玉敏[1] 

机构地区：[1]首都医科大学宣武医院脑血管病研究室,北京100053

出　　处：《首都医科大学学报》2014年第3期320-323,共4页Journal of Capital Medical University

基　　金：国家自然科学基金项目(81271461;81201028)~~

摘　　要：饮酒对中枢神经系统有重大影响,小胶质细胞是脑内原位免疫效应细胞,它在乙醇引起的神经毒性中有重要作用,可导致神经元死亡与退行性变;小胶质细胞有利于维持稳态而不是导致神经退行性变,小胶质细胞活化是乙醇引起损害的结果而不是损害的原因。本文对乙醇引起的神经元死亡和退行性变中小胶质细胞的反应及相应机制作一综述。Alcohol has a significant effect on the central nervous system, as the key immune effector cells in the brain, some studies proved that microglia plays an important role in the neurotoxicity of alcohol, which can lead to neuronal death and degeneration. Some investigations demonstrated that microglia is beneficial to maintain a steady state rather than causing nerve degeneration, microglia activation is the end of the damage induced by the alcohol rather than cause. This paper reviews the microglial response and related mechanism in neuronal death and degeneration caused by alcohol.

关 键 词：酒精性脑损伤 小胶质细胞 炎性反应 体内 体外 

分 类 号：R74[医药卫生—神经病学与精神病学]