SWI序列脾脏Gamna-Gandy小体数量在评价肝硬化门静脉高压程度中的作用  

The role of SWI in detecting the number of Gamna-Gandy bodies in spleen and its relationship with portal hypertension

作　　者：陶冉[1] 崔进国[1] 袁宏丽[1] 周祥峻[2] 田福存[2] 张久权[3] 王健[3] 

机构地区：[1]中国人民解放军白求恩国际和平医院放射科 [2]中国人民解放军66172部队医院 [3]第三军医大学西南医院放射科

出　　处：《中国临床医学影像杂志》2014年第6期397-400,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:本研究将磁敏感加权成像技术(Susceptibility-weighted imaging,SWI)应用于门静脉高压患者脾脏扫描,通过计算SWI序列上脾脏Gamna-Gandy小体(Gamna-Gandy body,GGB)的数量评价它在无创评价门静脉高压程度中的作用。方法:对135例肝硬化门静脉高压患者以及37例正常对照人群行SWI以及常规MR序列扫描并采集血液样本测量血小板数量。计算SWI序列代表层面上脾脏GGB数量。测量和比较正常对照组、GGB阴性组和GGB阳性组门静脉宽度,脾脏指数,血小板脾脏长径比值。将GGB数量分别与门静脉宽度、脾脏指数、血小板计数和血小板脾脏长径比值进行相关性分析。结果:SWI序列上门静脉高压患者脾脏GGB阳性例数为51例。GGB数量为40.9±28.4。GGB阳性患者门静脉横径、脾脏指数、血小板数量以及血小板数量和脾脏长径比值明显大于(或小于)正常对照者和GGB阴性患者。GGB阳性患者SWI序列上GGB的数量与门静脉宽度,脾脏指数呈明显正相关(r=0.624,P<0.001;r=0.502,P<0.001),与血小板计数以及血小板脾脏长径比值呈明显负相关(r=-0.373,P=0.007;r=-0.704,P<0.001)。结论:SWI序列上脾脏GGB数量可以作为一种无创的影像学方法判断肝硬化患者门静脉高压的程度。Objective： To detect Gamna-Gandy bodies（GGB） in spleen with susceptibility-weighted imaging（SWI） and to e- valuate the potential role of GGB number as a non-invasive marker of portal hypertention （PH）. Methods： SWI and conven- tional T1-, T2- and coronal T2-weighted imaging were performed on 135 patients with PH and on 37 control individuals. Platelet counts were collected from all PH patients. The portal vein diameter, splenic index （SI）, and platelet count/splenic length ratio were measured. The GGB numbers were counted on representative slice of SWI sequence in GGB-positive pa- tients. The portal vein diameter, SI, platelet count, and platelet count/splenic length ratio of control individuals were compared with those of GGB-negative and GGB-positive patients on SWI images. The correlations among GGB numbers, the portal vein diameter, the SI, the platelet count, and the platelet count/splenic length ratio were analyzed. Results： The GGB detection rate was 37.8%（51/135）. The number of GGB detected on representative slice of SWI was 40.9±28.4. The portal vein diameter, SI, platelet count, and the platelet count/splenic length ratio of GGB-positive patients were significantly higher （or lower） than that in the controls and GGB-negative patients. The number of GGB in the SWI images correlated positively with the portal vein diameter and SI, and correlated negatively with the platelet count and platelet count/spleen diameter ratio. Conclusion： The number of GGB on SWI may be a non-invasive marker for grading of PH.

关 键 词：高血压 门静脉 肝硬化 磁共振成像 

分 类 号：R575.21[医药卫生—消化系统] R445.2[医药卫生—内科学]