右美托咪定用于小儿脑瘫选择性脊神经后根切断术麻醉的研究  

Use of dexmedetomidine on children with cerebral palsy during selective dorsal root rhizotomy

作　　者：李京生[1] 田肇隆[1] 

机构地区：[1]首都医科大学宣武医院麻醉科,北京市100053

出　　处：《临床小儿外科杂志》2014年第3期246-249,共4页Journal of Clinical Pediatric Surgery

摘　　要：目的观察右美托咪定用于4,JL脑瘫选择性脊神经后根切断术麻醉的效果。方法选择30例行选择性脊神经后根切断术的患儿，随机分为右美托咪定组和对照组，每组15例，右美托咪定组于术中按0．2μg·kg^-1·h^-1持续泵人右美托咪定。两组术中麻醉维持按瑞芬太尼0．1～0．3μg·kg^-1·min^-1、丙泊酚2—6mg·kg^-1·h^-1持续泵人。记录两组不同时段SBP、HR、BIS、PETcO：，记录术中电刺激进行肌电（EMG）监测时患儿体动发生例数、术后躁动例数。结果右美托咪定组EMG监测时HR低于对照组，术中EMG监测时体动例数（0）及术后躁动例数（6．7％）少于对照组（13．3％，13．3％）。结论右美托咪定用于小儿脑瘫选择性脊神经后根切断术的麻醉维持，可使患儿术中生命体征更平稳，减少术后躁动发生。Objetive To observe the effect of dexmedetomidine given for children with cerebral palsy during selective dorsal root rhizotomy. Methods 30 children underwent selective dorsal root cut surgery were randomly divided into the dexmedetomidine group and control group, 15 cases in each group. In dexmedetomidine group, dexmedetomidine was given 0.2 μg · kg^- 1 · h ^- 1 continuously （ intravenous injection, iv）, Remifentanil（0. 1 ~0.3 μg · kg^-1·min^-1 ） and propofol （2 -6 mg · kg^-1 · h^-1 ） were used continuously to maintain anaesthesia in both groups. Recording SBP, HR, BIS and PrrCO2 in different periods, body movements during electrical stimulation EMG monitoring and postoperative agitation of each group. Results HR of dexmedetomidine group was lower than the contrel group during electrical stimulation EMG monitoring. The percentage of intraoperative body movements （0） and postoperative agitation（ 6.7% ） were less than the control group（ 13.3%, 13.3% ）. Conclusion Dexmedetomidine given for children with cerebral palsy during selective dorsal rhizotomy will maintain more stable vital signs and reduce the occurrence of postoperative agitation.

关 键 词：右美托咪定 脑性瘫痪 脊神经根切断术 儿童 

分 类 号：R742.3[医药卫生—神经病学与精神病学]