血管对高强度聚焦超声焦域影响的体模实验研究  

Experimental study on the effect of blood vessel on high intensity focused ultrasound focal region in phantom

作　　者：薛凡凡 常诗卉[1] 菅喜岐[1] 

机构地区：[1]天津医科大学生物医学工程学院,天津300070

出　　处：《天津医科大学学报》2014年第4期275-278,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(81272495)

摘　　要：目的:通过含蛋清的仿组织体模模拟血管,实验研究血流、血管位置及管径对高强度聚焦超声(HIFU)形成焦域的影响。方法:以模拟血液流动的仿组织体模血管模型为对象,在水槽进行HIFU辐照实验,分析一定超声治疗剂量条件下不同血流、血管位置和管径对血管周边形成变色焦域体积的影响及其变化规律。结果:血流对HIFU焦域有一定的冷却效应;焦点与血管距离越近,焦域受血管影响越明显;直径2 mm血管在声轴上且位于焦点之后时与焦点的距离大于3 mm,血管位于焦点之前且距离大于8 mm,血管对HIFU焦域的影响可以忽略不计;直径2 mm血管中心垂直偏离声轴大于3 mm时,血管对焦域的影响同样也可以不予考虑;管径越大在其周边形成的焦域体积越小。结论:血管与焦点的相对距离越远,血管对HIFU焦域的影响越小,当血管远离焦点一定距离时其影响可以忽略不计。Objective： To conduct an experiment with egg-white tissue-mimicking phantom containing simulated blood vessel to study the effect of blood vessels at different blood flow rates, locations and vessel diameters on high intensity focused ultrasound （HIFU） focal region. Methods： A phantom containing simulated blood vessel and blood flow was made with egg white,polyacrylamide etc. Experiments were performed in a degassed water tank under certain parameter condition. The volumes of the color-changing focal region formed by HIFU exposure were measured and the obtained data were statistically analyzed to discuss the effect of blood vessels at different blood flows, locations and diameters on HIFU focal region. Results： The cooling effect of vessel on focal region was observed during exposure. With decreased distance between vessel and focal point, the effect on focal region induced by blood vessel became more marked. The 2 mm blood vessel almost had no impact on the size of HIFU focal region when the blood vessel located on the acoustic axis at a distance larger than 8 mm to the focal point （before the focal point）, or a distance smaller than 3 mm （behind the focal point）. The effect of the blood vessel of 2 mm diameter was not significant when the vertical distance between the vessel center and the acoustic axis was larger than 3 mm. With increased vessel diameter, the volume of focal region near vessel became smaller. Conclusion： The longer the distance between the vessel and the focal point, the less effective of HIFU and can be neglected when a relative far distance is reached.

关 键 词：高强度聚焦超声 血管 仿组织体模 

分 类 号：R730.5[医药卫生—肿瘤]