SREPS对肝癌H22荷瘤小鼠的抑瘤作用  

Inhibitory effect of SREPS against H22 tumor-bearing mice

作　　者：程红兵[1] 陈云霞[1] 张雄鹰[1] 赵良启[2] 曹艳芳[3] 

机构地区：[1]长治医学院微生物学教研室,长治046000 [2]山西大学化学生物学与分子工程教育部重点实验室 [3]长治医学院附属和平医院

出　　处：《山西医科大学学报》2014年第6期447-449,共3页Journal of Shanxi Medical University

基　　金：山西省自然科学基金资助项目(2006011073);山西高校科技研究开发基金资助项目(20051203)

摘　　要：目的研究硫酸酯化细菌胞外多糖SREPS对肝癌H22荷瘤小鼠的抑瘤作用。方法 70只肝癌H22荷瘤小鼠随机分为7组:模型组、SREPS不同剂量组(0.5,1,2.5,5,10 mg/kg)和环磷酰胺组,腹腔注射,1次/d,连续10 d。于造模第11天观察抑瘤率、胸腺指数和脾指数。结果 SREPS不同剂量组(0.5,1,2.5,5,10 mg/kg)的抑瘤率分别为21.60%、23.50%,34.90%,26.50%和28.92%。与模型组比较,除0.5 mg/kg外,其余各浓度的瘤质量显著降低(P<0.05);SREPS不同剂量组可增加荷瘤小鼠的胸腺指数和脾指数,其中2.5 mg/kg剂量组对荷瘤小鼠胸腺指数和脾指数均显著增加(P<0.05)。结论SREPS对肝癌H22荷瘤小鼠有一定的抑瘤作用,SRESP在抑制肿瘤的同时可提高荷瘤小鼠的免疫功能。Objective To evaluate the inhibitory effect of sulfated rhizobium exopolysaccharide （SREPS） against the H22 tumor - bearing mice. Methods H22 tumor-bearing mice were randomly divided into model group, cyclophosphamide group, SREPS groups （0.5,1,2.5,5,10 mg/kg）. After 10 d treatment,the inhibitive rate,thymus index and spleen index were observed and recorded. Re- sults The inhibitory rates respectively were 21.60%,23.50%,34.90%,26.50% and 28.92% after treated with 0.5,1,2.5,5,10 mg/ kg SREPS ,respectively. Compared with model group,the weight of tumor significantly decreased in SREPS groups except 0.5 mg/kg（ P 〈 0.05 ）. Compared with model group, the weight of immune organs and the spleen and thymus index significantly increased in SREPS groups, especially in 2.5 mg/kg group. Conclusion SREPS have inhibitory effect on H22 growth in tumor-bearing mice, and can improve the immune function.

关 键 词：硫酸酯化多糖 肝癌H22 抑瘤率 胸腺指数 脾指数 

分 类 号：R735.7[医药卫生—肿瘤]