β-catenin和Ki67在涎腺腺泡细胞癌中的表达及意义  

The expression of β-catenin and Ki67 in acinic cell carcinoma of salivary gland and its significance

作　　者：张丽慧[1] 吴兰雁[2] 姚甜 赵业[4] 郑亚鸽[5] 

机构地区：[1]陕西省西安医学院口腔系,西安710021 [2]四川大学华西口腔医院病理科 [3]中国解放军第四一一医院 [4]山西大同市第三人民医院口腔科 [5]成都市双流县妇幼保健院

出　　处：《山西医科大学学报》2014年第6期474-477,549,共5页Journal of Shanxi Medical University

基　　金：陕西省教育厅自然科学专项基金资助项目(2013JK0790)

摘　　要：目的探讨β-catenin和Ki67在预测涎腺腺泡细胞癌(AciCC)预后中可能的价值。方法采用免疫组化PV两步法分别检测β-catenin和Ki67蛋白在46例AciCC、10例腮腺肿瘤瘤旁正常组织中的表达情况,并对相关临床病例参数进行比较。结果 46例AciCC中18例复发,6例发生淋巴结转移。β-catenin的异常表达在AciCC复发组高于无复发组(P<0.05);Ki67的标记指数≥10%时,复发率较高(P<0.01),淋巴结转移率较高(P<0.01)。结论β-catenin和Ki67表达可以作为预测AciCC预后的辅助因子。Objective To investigate the clinical value of β-catenin and Ki67 in predicting the prognosis of acinic cell carcinoma in salivary. Methods The expression of β-catenin and Ki67 in 46 cases of acinic cell carcinoma and 10 cases of their adjacent normal tissues were detected by inmmunohistochemical staining （ PV two - steps）. The correlation of expression of β-catenin and Ki67 with prognosis was analyzed. Results Of 46 cases, 18 cases recurred, and 6 cases were found lymph node metastasis. The abnormal expression of β-catenin in recurrent group was higher than that in non - recurrent group （ P 〈 0.05 ）. The incidences of recurrence and lymph node metastasis were higher in acinic cell carcinoma patients with label index（L1） of Ki67 t〉 10% （P 〈 0.01 ）. Conclusion The β-catenin and Ki67 might be useful markers in prediction of the prognosis of acinic cell carcinoma.

关 键 词：涎腺 腺泡细胞癌 Β-CATENIN KI67 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]