没食子酸的药理作用及其药物代谢动力学研究进展  

Research progress of pharmacological action and pharmacokinetics of gallic acid

作　　者：高雅[1] 李骅[2,3] 王四旺[2,3] 谢艳华[2,3] 杨倩[2,3] 张邦乐[3,4] 

机构地区：[1]第四军医大学药学系学员队,西安710032 [2]第四军医大学药学系天然药物学教研室,西安710032 [3]秦巴山区中药发展协同创新中心,西安710032 [4]第四军医大学药学系药剂学教研室,西安710032

出　　处：《西北药学杂志》2014年第4期435-438,共4页Northwest Pharmaceutical Journal

摘　　要：目的综述中药及其复方制剂中的药效分子没食子酸(gallic acid,GA)的药理和药物动力学等研究进展,为进一步研究GA提供参考。方法查阅国内外文献,总结、提炼和阐明GA的研究现状和前景。结果 GA是牡丹皮、山茱萸等中药及其复方制剂中重要的功效成分,具有明显抗肿瘤、抗炎、抗氧化、抑菌和心脑血管保护等药理作用。经灌胃及静脉给药后,GA在动物体内的药代动力学过程均符合二室模型,大鼠灌胃给药的绝对生物利用度为42.9%。结论 GA作为牡丹皮等中药及其复方制剂中有效的中药分子用于开发抗心脑血管疾病、抗菌消炎、抗肿瘤的药物具有良好的前景。Objective To review the pharmacological action and pharmacokinetic researches of gallic acid（GA）which is an active molecule widely distributed in traditional Chinese medicine（TCM）and its related preparations so as to provide a comprehensive insight for the further research of GA.Methods The research progress and the future research of GA were summarized by reviewing literatures.Results GA is an important active component which called active molecule of Chinese medicinal materials（AMCMM）of Fructus Corni,Cortex Moutan and their related TCM preparations.GA has significant pharmacological effects including cardio and cerebro-protective effects,antitumor,anti-inflammation and antibacterial activities.A two-compartment first order absorption model could describe the pharmacokinetics of GA in experimental animals after intravenous and oral administration.The absolute bioavailability was 42.9%.Conclusion GA has a good prospect of development for treating coronary heart disease and other diseases as an AMCMM from Cortex Moutan and its related TCM preparations.

关 键 词：没食子酸 药理活性 药代动力学 中医药 

分 类 号：R285[医药卫生—中药学]