肥胖妇女的肺功能:引证方程和背景的重要性(英文)  

PULMONARY FUNCTION IN OBESE WOMEN:IMPORTANCE OF REFERENCE EQUATIONS AND RACIAL BACKGROUND

作　　者：Vipa Bernhardt Matthew D.Spencer Tony G.Babb 

机构地区：[1]Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas The University of Texas Southwestern Medical Center

出　　处：《青海医学院学报》2014年第2期73-81,91,共10页Journal of Qinghai Medical College

基　　金：supported by the National Institutes of Health( Grant HL096782);King Charitable Foundation Trust;American Heart Association;Cain Foundation;Texas Health Presbyterian Hospital Dallas

摘　　要：肥胖可改变肺功能。但目前的相关研究尚不能证明美国非洲裔（AA）、高加索裔（C）及拉美裔（H）肥胖妇女在肺活量、肺容积及弥散能力（DLCO）方面有何区别。而对其影响能力大小的评估往往由于其使用的引证方程不同而被混淆。因此，本研究的目的是探讨具不同背景的种族或族群肥胖妇女与肥胖相关的肺活量、肺容积及弥散能力，并使用各种不同而广泛使用的引证方程进行计算。本研究对40名美国非洲裔、25名高加索裔及15名拉美裔健康肥胖妇女（范围：超重的体脂肪在32％-55％之间）在体积描记器上进行了肺活量、肺容积及弥散能力的测定。用配对t检验和方差分析对引证方程进行了比较。用方程处理的各组年龄、血球容积、体重和基础代谢率相似；肺活量方面，即使观察到种族和族群间有较小的差别，但大致处于正常范围（FVC≈100％～115％；FEV1≈97％～107％）；使用不同的引证方程计算，尽管总肺活量正常（≈98％～103％），但功能余气量偏低（≈75％～80％）或正常（≈90％～95％）；无论用何种方程，余气量也是低的（≈60％～70％）；肺弥散能力稍低（≈73％～91％）；而DLCO／VA则正常（≈90％～110％）。我们的实验表明，肥胖对肺功能的影响独立于种族和族群的背景。在解释肺功能数据时应充分注意肥胖、种族和引证方程等方面的因素。Obesity alters pulmonary function. However, it is unknown whether spirometry, lung volume subdivisions and/or diffusing capacity （DLCO）differ among African American （ AA ）, Caucasian （ C ） and Hispanic （H） obese women, or whether the magnitude of effect is confounded by the reference equations Used. Thus the aim was to investigate obesity -related changes in spirometry, lung volumes, and DLCO among obese women of different racial/ethnic backgrounds using a variety of widelyused reference equations. 40 AA,25 C, and 15 H, otherwise healthy obese women（ range ： 32% ～ 55% body fat） performed spirometry, lung volumes and DLco assessments in a body plethysmograph. Reference equations were compared using paired t - test and ANOVA. Age, Ht, Wt, and BMI were similar among groups. Regardless of the quation used, spirometry was normal （ FVC ≈ 100% 115% ;FEV1 ≈97% ～ 107% ） ,though small equation -specific racial/ethnic differences were observed. Despite normal TLC values（ ≈98% ～103% ）, FRC tended to be low（ ≈75% ～80% ）or normal（ ≈90% ～95% ）depending on the equation used;RV was also low（ ≈60%～70% ）regardless of equation. DLco was somewhat low（ ≈73% ～91% ） ;yet, DLCO/VA was normal（ ≈90% ～ 110% ）. The effects of obesity on pulmonary function are largely independent of racial/ethnic background. Caution should be exercised when interpreting pulmonary function data in regards to the effects of obesity, race, and reference equations.

关 键 词：肥胖妇女 肺功能 方程 引证 肺弥散能力 肺活量 配对T检验 基础代谢率 

分 类 号：R363.16[医药卫生—病理学]