皖北地区123例胃食管反流病食管外表现的发病情况研究  

A survey on prevalence of extraesophageal symptoms of gastroesophageal reflux disease in northern Anhui province

作　　者：邓敏[1] 王启之[1] 燕善军[1] 李大鹏[1] 汪强武[1] 刘晓阳[1] 顾林[1] 薛永举[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院消化科,233004

出　　处：《中华全科医学》2014年第9期1446-1448,共3页Chinese Journal of General Practice

摘　　要：目的探讨皖北地区胃食管反流病(GERD)食管外表现(EES)的发病情况及其对生活质量的影响。方法本研究入选患者,均具有典型的GERD症状。入组患者进行GerdQ量表和食管外相关症状的问卷调查并记录积分,所有患者均进行内镜检查然后分为ERD组和NERD组,然后对上述资料进行统计、比较分析。结果共分析123例GERD患者,伴有EES者111例,NERD69例。其中50名患者(41.0%)认为他们在过去的一周内存在因烧心和/或反流而导致的睡眠困难。在ERD患者中睡眠障碍比NERD更普遍。额外服用非处方药在ERD患者中也比NERD患者更常见。EES的总的发病率在性别、年龄、吸烟状态、BMI和有无内镜下反流性食管炎之间并无差异。EES最常见是上腹部烧灼不适,其次为慢性咽炎、胸痛、咳嗽、声音嘶哑和哮喘。其发生率分别为:73.2%、51.8%、48.4%、32.0%、24.2%、17.3%。ERD患者与NERD患者相比而言,其每一种EES的发生均有显著差异。GerdQ评分≥8分的患者中每一种EES的发生率均比<8分的患者显著升高。EES的评分在目前吸烟的患者中比以前吸烟或从不吸烟的高。在ERD患者中EES的评分比NERD患者高。50例患者(41.0%)存在睡眠障碍。结论皖北地区GERD患者的EES相当普遍。相对于NERD患者而言,ERD患者的EES发生率更加常见。Objective To survey the prevalence of extraesophageal symptoms（ EESs） of gastroesophageal reflux disease（ GERD） in northern anhui province and evaluate its influence on the quality of life（ QOL） of patients. Methods Total123 patients with typical symptoms of GERD were enrolled in this study. The GerdQ and EESs questionnaire were carried in all patients. They were divided into erosive reflux disease（ ERD） group（ 54 cases） and non-erosive reflux disease（ NERD） group（ 69 cases） based on the results of endoscopic examination. The data were compared and analyzed by statistical methods. Results 111 patients were with EES. 50 patients（ 41. 0%） complained of dyscoimesis resulted from the acid reflux in the last week. The incidence of dyscoimesis in the ERD group was higher than that in the NERD group. The rate of the additional taking of OTC in the ERD group was higher than that in the NERD group. There was no correlation between the total incidence of EES and gender,age,tobacco use,body mass index and reflux esophagitis under endoscope.The most prevalent symptoms of EES were the burning sensation in the upper epigastric region（ 73. 2%）,followed by chronic pharyngitis（ 51. 8%）,chest pain（ 48. 4%）,cough（ 32. 0%）,and hoarseness（ 24. 2%） and wheezing（ 17. 3%）.The difference among them was statistical significant. The incidence of EES in the patients with GerdQ sum score of 8 or more was obviously higher as compared with the patients with GerdQ sum score less than 8. The score for EES in the patients using tobacco was higher than that in patient quitted smoking or without a history of tobacco use. The score for EES in the ERD group was higher than that in the NERD group. There were 50 patients with dyscoimesis. Conclusion The prevalence of EES is high in the patients with symptomatic GERD in Northern Anhui province. EES is more prevalent in patients with ERD as compared to those with NERD.

关 键 词：EES 胃食管反流病 发病 

分 类 号：R57[医药卫生—消化系统] R195[医药卫生—内科学]