脑源性神经营养因子基因与生活事件交互作用对抑郁自杀未遂的影响  

Interaction between BDNF Gene and Life Events on Depressive Suicide Attempters

作　　者：任燕[1,2] 王彦芳[2] 彭菊意[1] 杜巧荣[2] 张克让[2] 杨红[1] 

机构地区：[1]山西医学科学院-山西大医院精神卫生科,中国太原030032 [2]山西医科大学第一医院精神卫生科

出　　处：《中国健康心理学杂志》2014年第7期967-969,共3页China Journal of Health Psychology

基　　金：山西省科技攻关项目(编号:20110313012-1);山西省青年科技研究基金(2010021036-3);山西省卫生厅科技攻关计划项目(编号:20100110);山西医科大学青年基金(编号:057405)

摘　　要：目的探讨脑源性神经营养因子(BDNF)基因与生活事件交互作用对于抑郁障碍自杀未遂患者的影响。方法收集伴自杀未遂行为的重性抑郁障碍患者和无自杀未遂的重性抑郁障碍患者各80例,评定汉密尔顿抑郁量表、生活事件量表,采用聚合酶链反应技术(PCR)对BDNF基因多态性进行基因分型,应用MDR软件包分析基因-环境交互作用。结果①与重性抑郁障碍无自杀未遂组相比,重性抑郁障碍自杀未遂组rs6265 AA基因型频率较高,差异具有统计学意义(χ2=7.380,P=0.025);自杀未遂组A等位基因频率较高,差异具有统计学意义(χ2=4.081,P=0.043)。②MDR结果显示,BDNF rs6265基因多态性与负性生活事件存在交互作用模型,该模型的检验样本误差较小(0.4686),交叉验证一致性为10/10,符号检验P<0.001。结论 BDNF rs6265基因多态性与负性生活事件之间存在交互作用,该交互作用与重性抑郁障碍自杀未遂行为发生相关。Objective To investigate the interaction between brain-derived neurotrophic factor gene and life events ,and reveal its af-fect on the depressive patients attempting suicide .Methods A total of 80 major depressive disorder patients with suicide attempts and 80 major depressive disorder patients without suicide attempts were assessed using Hamilton Depression Rating Scale and the Life Events Scale,polymerase chain reaction（PCR）were used to detect the genetic polymorphism of the BDNF gene and MDR software were applied to test the gene-environment interactions .Results Compared with major depressive disorder patients without suicide attempts , the rs6265 AA genotype frequency was higher in those with suicides attempts （χ2 =7.380,P〈0.05）;The A allele frequency was also statis-tically significantly higher （χ2 =4.081,P〈0.05）.There was a best model of interaction between BDNF rs 6265 and negative life e-vents,the test samples of the model error was small （0.4686）,cross-validation consistency was 10 /10,sign test P〈0.001.Conclusion There is an interaction between BDNF rs 6265 polymorphism and negative life events ,and this interaction maybe associated with suicide attempts in major depressive disorder patients .

关 键 词：抑郁障碍 自杀未遂 交互作用 脑源性神经营养因子 生活事件 

分 类 号：R749.4[医药卫生—神经病学与精神病学] B849[医药卫生—临床医学]