健脾化痰法联合肝动脉导管化疗栓塞序贯射频消融治疗大肝癌的临床研究  

Clinical Study on Large Hepatocellular Carcinoma Treated with Jianpi Huatan Therapy Combined with Radiofrequency Ablation( RFA ) after Transcatheter Arterial Chemoembolization( TACE)

作　　者：宋来成[1] 张连业[1] 苗秀英[1] 苏红宝[1] 怀德过 

机构地区：[1]安徽中医药大学附属太和县中医院,安徽太和236607

出　　处：《世界中西医结合杂志》2014年第6期634-637,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的：评价中药联合肝动脉导管化疗栓塞（TACE）后序贯射频消融（RFA）治疗大肝癌的疗效。方法72例（95个病灶）大肝癌患者（肿瘤直径5.1-14.5 cm），TACE 治疗后1周行 RFA治疗，24 h CT 评价，如有漏空现象，给予 RFA 1-2次补充治疗，最后一次 RFA 治疗后1个月再次行TACE 巩固治疗。术后所有患者均服用中药健脾化痰方。随访观察治疗效果、并发症和患者生存时间。结果 RFA 后完全缓解36例，部分缓解22例，病变进展14例。并发症7例（9.72%），包括电极片灼伤皮肤2例，气胸3例，腹腔出血2例。大肝癌 TACE 序贯 RFA 治疗后6个月、1、2、3年生存率分别为97.2%（70例）、73.6%（53例）、47.2%（34例）、33.3%（24例）。结论中药联合 TACE 后序贯RFA 是治疗大肝癌的一种有效治疗模式。Objective To evaluate the efficacy on large hepatocellular carcinoma（HCC）treated with Chinese medicines combined with radiofrequency ablation（RFA）after transcatheter arterial chemoemboliza-tion（TACE）. Methods Seventy - two cases of large HHC had 95 foci（5. 1 - 14. 5 cm in diameter）. RFA was applied after TACE. CT assessment was given in 24 h. RFA for one or twice were supplemented if leaka-ges were discovered. TACE was consolidated after the last RFA in one month. Results Thirty - six cases were completed ablated after RFA,22 cases basically ablated and 14 cases partially ablated. Seven cases （9. 72% ）presented complications,including 2 cases of skin burns,3 cases of pneumothorax and 2 cases of abdominal hemorrhage. The survival rates were 97. 2%（70 cases）,73. 6%（53 cases）,47. 2%（34 cases）and 33. 3%（24 cases）in 6 months,1,2 and 3 years after RFA after TACE separately. Conclusion Chinese medi-cines combined with RFA after TACE is the effective therapeutic program for the treatment of large HCC.

关 键 词：大肝癌 射频消融 肝动脉导管化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤]