微小RNA与胶质瘤干细胞放化疗敏感性  

Effect of miRNA on radiosensitivity and chemosensitivity in glioma stem cells

作　　者：陈嘉荣[1] 孙权权[1] 张天[1] 路艳蒙[2] 袁亚维[1] 

机构地区：[1]南方医科大学南方医院放疗科,广州510515 [2]南方医科大学电镜室

出　　处：《国际肿瘤学杂志》2014年第6期405-407,共3页Journal of International Oncology

基　　金：高等学校博士学科点专项科研基金（20114433110015）

摘　　要：微小RNA（miRNA）的表达与胶质瘤干细胞对放疗及化疗的敏感程度密切相关。许多研究发现，调节单一miRNA能起到提高胶质瘤干细胞的放化疗敏感性、增加细胞凋亡、多方面综合抑制胶质瘤干细胞生长的效果。胶质瘤的治疗策略有望以miRNA为靶点，通过调节miRNA在细胞中的表达，从而达到提高胶质瘤干细胞放化疗敏感性的目的。The expression of microRNA （miRNA） is closely related to radio-chemosensitivity in glioma stem cells （GSCs）. Moreover, the growth of glioma stem ceUs could be inhibited comprehensively by increasing radio-chemosensitivity and apoptosis, simultaneously with the regulation of a single miRNA, which has been confirmed by some researches. Thereby microRNA is prospective for the adoption as a specific agent in targeted therapy of glioma, so as to increase the radio-chemosensitivity in glioma stem ceils.

关 键 词：微RNAS 神经胶质瘤 肿瘤干细胞 放射疗法 药物疗法 

分 类 号：R739.4[医药卫生—肿瘤] R730.55[医药卫生—临床医学]