甲状腺肿瘤ras-p21及EBV/LMP-1的表达及意义  

THE EXPRESSION AND SIGNIFICANCE OF ras-p21 AND EBV LMP-1 IN THYROID NEOPLASM

作　　者：张廷国[1] 任国锋[1] 周庚寅[1] 刘文君[1] 

机构地区：[1]山东大学医学院病理学教研室

出　　处：《山东医科大学学报》2001年第1期32-34,37,共3页Acta Academiae Medicinae Shandong

摘　　要：目的 :研究ras癌基因及EBV感染在甲状腺癌中的意义。方法 :应用SABC免疫组化法对88例甲状腺肿瘤 (乳头状癌 34例 ,滤泡性癌 17例 ,髓样癌 5例 ,未分化癌 8例 ,腺瘤 2 4例 )进行研究 ,观察ras癌基因蛋白产物p2 1及EBVLMP 1的表达情况。 结果 :甲状腺癌 p2 1的表达与甲状腺肿瘤良恶性有关 ,甲状腺癌 p2 1阳性率 ( 62 5% )明显高于甲状腺腺瘤 ( 33 3% ) (P <0 0 5)。甲状腺癌 p2 1与组织学分型无关。LMP 1在甲状腺癌中的表达率为 15 6% ,癌周组织无表达。结论 :ras癌基因突变为甲状腺癌发生中的早期事件 ,p2 1检测可作为甲状腺滤泡性肿瘤良恶性鉴别的辅助指标 ,提示EBV感染与甲状腺癌的发生有关。Objective:Study the relationship between oncogene、Epstein Barr virus and thyroid tumors.Methods:88 cases of thyroid neoplasms including 34 cases of papillary carcinoma.17 cases of follicular carcinoma,5 cases of medullary carcinoma,8 cases of undifferentiated carcinoma and 24 cases of thyroid adenoma were studied by immunohistochemical method using antibodies to p21,EBV LMP 1.Results:Positive rate of p21 was higher in thyroid carcinomas(62.5%) than in adenomas(33.3%)(P<0.05).p21 expression wasn't related to histological types(P>0.05).Conclusion:Ras oncogene mutation plays an important role in early stage of thyroid carcinoma.Epstein Barr virus latent membrane protein was mainly located in cytoplasm and rare in nucleus.Positive rate in thyroid carcinoma was 15.6%(10/64).Normal tissue around the carcinoma was negative.Some thyroid carcinomas may be related to EB virus infection.

关 键 词：甲状腺肿瘤 免疫组织化学 RAS-P21 EBV LMP-1 表达 

分 类 号：R736.1[医药卫生—肿瘤]