血清同型半胱氨酸、叶酸、维生素B_12浓度与多发性硬化的关系研究  

Study on Relationship between Homocysteine,Folic Acid,Vitamin B_(12) and Multiple Sclerosis

作　　者：张建磊[1] 李郭飞[1] 常娜[1] 王朝辉[1] 刘大建[1] 贺维亚[1] 

机构地区：[1]河南大学淮河医院,河南开封475000

出　　处：《中国医学创新》2014年第18期54-56,共3页Medical Innovation of China

基　　金：河南省科技厅基础与前沿技术研究项目(132300410383)

摘　　要：目的:探讨血清同型半胱氨酸水平(Hcy)与多发性硬化(MS)的关系。方法:检测41例MS患者(MS组)和42例正常对照者(NC组)血清中Hcy浓度、叶酸及维生素B12浓度,并将结果进行比较分析。结果:MS组和NC组血清中Hcy浓度分别为(25.82±1.724)μmol/L、(13.60±1.517)μmol/L。MS组的Hcy浓度明显高于NC组,差异有统计学意义(P<0.01),而两组的叶酸、维生素B12浓度比较差异均无统计学意义(P>0.05)。结论:MS患者血清Hcy水平升高,同型半胱氨酸可能在多发性硬化病理过程中起作用。To investigate the relationship between the serum level of homocysteine（Hcy）and multiple sclerosis（MS）.Method：The concentration of Hcy,folic acid and vitamin B12 in serum in 41 MS patients（MS group）and 42 normal controls（NC group）were detected,and the results were compared and analyzed.Result：The mean concentrations of Hcy in MS group and NC group were（25.82±1.724）μmol/L,（13.60±1.517）μmol/L respectively. The mean concentration of Hcy in the MS group was significantly higher than the NC group,the difference was statistically significant（P〈0.01）,while there were no statistically significant differences in folic acid and vitamin B12 between the two groups（P〉0.05）.Conclusion：The level of Hcy is higher in MS patients,homocysteine may play a role in the pathological process of multiple sclerosis.

关 键 词：多发性硬化 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R744.51[医药卫生—神经病学与精神病学]