糖原合酶激酶3信号通路的细胞保护作用机制  

The Protection Mechanism of GSK-3 Signaling Pathway for Cells

作　　者：朱江兰[1] 石蓓[1] 

机构地区：[1]遵义医学院附属医院心血管内科,贵州遵义563003

出　　处：《医学综述》2014年第11期1945-1947,共3页Medical Recapitulate

摘　　要：糖原合酶激酶3(GSK-3)广泛发分布于人类及动物的组织细胞中,是许多信号调节通路的交汇点,与多种疾病的发生密切相关。GSK-3的两个亚型(α及β)在结构上虽然有相似之处,但是功能上有显著差异,两者的组织特异性也有不同之处。该文就GSK-3的基本结构和功能进行阐述,从GSK-3与心脏疾病、糖尿病、缺血性视网膜病及肿瘤等方面的关系概述GSK-3如何发挥细胞保护作用。The glycogen synthase kinase 3 （GSK-3） is widely distributed in the tissues and cells of human and other animals. It is the intersection of many signal conditioning channels so that it is closely related with a variety of diseases. Although the two subtypes of GSK-3 （ α and β ） are similar in structure, there is a significant difference in function, so does the tissue specificity. Here is to elaborate the basic structure and function of GSK-3, and state how it protects ceils from the its relationship with heart disease, diabetes, ischemic retinal disease and tumor.

关 键 词：糖原合酶激酶3 心脏疾病 糖尿病 缺血性视网膜病 肿瘤 

分 类 号：R363.21[医药卫生—病理学]