乙型肝炎病毒致肝细胞癌发生机制研究进展  

Hepatitis B virus- associated mechanisms of hepatocellular carcinoma

作　　者：郭恩爽 周福元[1] 

机构地区：[1]南方医科大学南方医院感染内科,广州市510515

出　　处：《实用肝脏病杂志》2014年第4期437-440,共4页Journal of Practical Hepatology

摘　　要：肝细胞癌(HCC)的发生与乙型肝炎病毒(HBV)感染密切相关。HBV感染所致的炎症反应、HBV X基因及其产物X蛋白、核心启动子突变、前S2区突变、剪接特异性蛋白等均可能参与HCC的发生发展。The infection of hepatitis B virus （HBV） plays an important role in the occurrence of hepatocellular carcinoma （HCC）. Multiple factors may be involved in the hepatocarcinogenesis of HBV-related HCC,such as inflammatory response,HBV X gene and its protein,the mutation of HBV core promoter and pre-S 2 genes,HBV spliced protein and so on. We will discuss some progresses in this field.

关 键 词：肝细胞癌 乙型肝炎病毒 发生机制 

分 类 号：R735.7[医药卫生—肿瘤]