维生素C对大鼠实验性根尖周炎影响的初步研究  

The effect of vitamin C on the progress of the rat periapical periodontitis

作　　者：陈铭清 朱泽群[1] 周红艳[1] 杨颜菁[1] 曹灵[1] 梅予锋[1] 王珏[1] 

机构地区：[1]南京医科大学口腔医学研究所.附属口腔医院儿童口腔预防科,江苏南京210029

出　　处：《口腔生物医学》2014年第2期71-74,共4页Oral Biomedicine

基　　金：南京医科大学科技发展基金面上项目(ZC32012006);江苏高校优势学科建设工程资助项目(2014-37)

摘　　要：目的:探讨维生素C对大鼠实验性根尖周炎形成过程的影响。方法:选用100只8周龄Wistar雄性大鼠,髄腔直接暴露法建立根尖周炎模型,将大鼠分成维生素C干预组(0.1、0.5、1.0 mg/mL维生素C灌胃)及对照组,术后1、3、7、14、21 d处死,通过X线测量法和HE染色观察根尖周病变的大小和组织学变化。结果:维生素C干预组和对照组根尖透射区的面积从3 d开始增大,呈时间依赖性,21 d时透射面积到达高峰。术后7、14、21 d维生素C干预组的根尖透射区的面积均小于对照组,差异具有统计学意义(P<0.05),其中0.1 mg/mL组根尖透射区的面积明显小于其它各组(P<0.05)。术后7、14、21 d维生素C干预各组骨吸收陷窝数及牙槽骨破坏范围均小于对照组。结论:全身应用维生素C对抑制大鼠根尖周炎的进展有一定的作用。Objective：To explore the effect of vitamin C on the development of the induced rat periapical periodontitis.Methods：Periapical disease was induced by pulp exposure of the mandibular first molar on 100 male Wistar rats （8-week-old）.Rats were divided into vitamin C groups （0,0.1,0.5 and 1 mg/mL,respectively）and a normal group,then were sacrificed on day1,3,7,14 and 21.We measured the area of the periapical lesions by radiographs and obtain histological results by HE staining.Results：Periapical lesions were significantly expanded from day 3 onwards,in a time-dependent manner,and peaked on day 21.There was no difference between day 1 and 3.On day 7,14 and 21,the periapical lesion areas of practiced groups were remarkably lower than that of the control group. The periapical lesions of the 0.1 mg/mL group was the lowest among all practiced groups.Vitamin C groups also had less bone resorption lacunae and smaller alveolar bone destruction.Conclusions：To some extent,vitamin C effectively inhibited the progress of the rat periapical periodontitis.

关 键 词：维生素C 根尖周炎 大鼠 

分 类 号：R781.3[医药卫生—口腔医学]