牛蒡苷元对自发性高血压大鼠的降压及对靶器官的保护作用  

Hypotensive and target organs protective effects of arctigenin on SHR

作　　者：刘影[1] 郭福川[1] 张宇秋[1] 李松涛[1] 李颖[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,黑龙江哈尔滨150081

出　　处：《中国公共卫生管理》2014年第3期321-323,共3页Chinese Journal of Public Health Management

基　　金：哈尔滨市科技创新人才研究专项资金项目(2010RFQXS068);黑龙江省教育厅(11551243);黑龙江省卫生厅(2009-220)

摘　　要：目的研究牛蒡苷元(ARC-G)对自发性高血压大鼠(SHR)和正常Wistar大鼠血压的调节、靶器官的保护作用。方法 12周龄的SHRs(280g^320g)40只随机分为牛蒡苷元高、中、低剂量组(100mg/kg、50mg/kg、25mg/kg),硝苯地平(3mg/kg)阳性对照组,溶剂对照组;相应周龄的Wistar大鼠16只,随机分为牛蒡苷元(100mg/kg)和溶剂对照组。所有溶剂均为1%羧甲基纤维素,灌胃给药8周。观察牛蒡苷元对SHR和Wistar大鼠血压、心、肾高血压主要靶器官质量指数的影响。结果牛蒡苷元对各组大鼠体重无影响,但可剂量依赖性地降低SHR大鼠血压;牛蒡苷元和硝苯地平能明显抑制SHR左心室肥厚,SHR各组的SBP和左室质量指数、肾脏质量指数均明显高于同龄Wistar大鼠(P<0.01)。给药治疗2周后,与SHR对照组比较ARC-G高中剂量组可明显降低SBP(P<0.05或P<0.01),可明显降低左室质量指数(P<0.05或P<0.01);对肾脏质量指数无明显影响(P>0.05);牛蒡苷元对Wistar大鼠各指标均无明显影响,与对照组相比(P>0.05)。结论牛蒡苷元对SHR有降压及逆转左心室肥厚的作用。Objective To investigate hypotensive and target organs protective effecs of long-term treatment with aretigenin （ARC-G）. Methods Forty 12-week-old male SHR（280-320g） were randomly assigned to five groups （aretigenin 100mg/ kg, arctigenin 50mg/kg, arctigenin 25mg/kg nifedipine3mg/kg, SHR vehicle） and matched Wistar rats were randomly assigned to two groups （Wistar＋aretigeninlO0mg/kg and Wistar vehicle）. All animals were treated for 8 weeks. Systolic blood pressure was determined every other week. Bodyweight was determined every week. Cardiac and renal morphology were examined. Results Chronic arctigenin treatment reduced systolic blood pressure in a dose dependent manner, and significantly reduced left ventricular hypertrophy. The efficianey of arctigenin （50,100mg/kg） is similar to nifedipine. Conclusion Aretigenin can decrease high blood pressure and reverse left ventrieular hypotrophy in SHR.

关 键 词：牛蒡苷元 自发性高血压大鼠 血压 靶器官保护 

分 类 号：R965[医药卫生—药理学]