熊去氧胆酸配合凯西来注射液抗肝纤维化临床研究  

and Kaixilai root on hepatic anti - fibrosis.

作　　者：康克嘉 

机构地区：[1]沈阳市第五人民医院,辽宁沈阳110023

出　　处：《健康大视野（医学版）》2014年第2期11-12,共2页Health Horizon:Medical Science Fascicule

摘　　要：目的观察熊去氧胆酸配合凯西来注射液抗肝纤维化的治疗效果。方法用熊去氧胆酸配合凯西来注射液治疗肝硬化患者35例；另设30例复方丹参治疗为对照组，治疗前后观察临床表现、检测肝功能，测定血清透明质酸（HA），层粘连蛋白（LN），Ⅳ型胶原（Ⅳ—C），Ⅲ型前胶原肽（PⅢP）。治疗组临床表现改善明显优于对照组（P〈0．05），总有效率优于对照组（P〈0．05）。肝功能改善及HA、LN、PⅢP、Ⅳ-C的降低明显优于对照组。熊去氧胆酸配合凯西来注射液治疗肝硬化具有明显的保肝、抗肝纤维化作用。Objective To observe the therapeutic effect of Xiongquyangdanshuan and Kaixilai root on hepatic anti -fibrosis. Methods The patients with liver cirrhosis were randomly divided into two groups（ treated group and control group）. The treated group（ 35 patients）were treated with Xiongquyangdanshuan and Kaixilai root, while the Control group（ 30 patients） were treated with compound Danshen root. the manifestation, hepatic function, hyaluronic acid （HA） , laminin （ LN ） , type Ⅳ collagen （ Ⅳ - C ） and preeollagen type Ⅲ peptide （ PC Ⅲ P） of before and after treatment was observed. Results It was found that the degree of the improvement of manifestation, hepatic function, HA, and LN Ⅳ - C of the treated grounp was higher than that of the Control group significantly （ P 〈 0.05 ）, and the therapeutic efficacy of the treated grounp was better than that of the control group significantly（ P 〈 0.05 ）. Conclusions Xiongquyangdanshuan and Kaixilai root have evident prevention and treatment effect.

关 键 词：熊去氧胆酸配合凯西来注射液 抗肝纤维化 临床研究 

分 类 号：R575[医药卫生—消化系统]