组织弥散定量分析运用于肝纤维化程度判定的研究  

The application of quantitative analysis of tissue diffusion in the degree of liver fibrosis

作　　者：靳元[1] 

机构地区：[1]黑龙江省大庆龙南医院物理诊断科(齐齐哈尔医学院第五附属医院),黑龙江大庆163453

出　　处：《医学影像学杂志》2014年第6期970-972,976,共4页Journal of Medical Imaging

摘　　要：目的：探讨超声弹性成像组织弥散定量分析对肝纤维化程度判定的应用价值，以期为肝病患者的病情评估及早期预防提供方法。方法选取2011年1月～2013年7月消化内科150例慢性乙肝患者为试验组研究对象，行肝脏穿刺术，根据肝纤维化病理分期标准分为5期（S0～S4）。另选取健康志愿者40例为对照组。所有研究对象均行超声成像检查组织弥散定量分析。比较试验组与对照组研究对象中11项组织弥散特征量之间的差异性，并根据统计学结果，将有统计学意义的指标进行试验组不同病理分期患者组内比较，并分析其与肝纤维化病理分期的相关性。结果在11个弹性特征量中，试验组应变均值较对照组明显降低，蓝色领域百分比较对照组明显增高，差异有统计学意义（P均＜0.05）。在试验组患者中，随着肝纤维化病理分期的增高，应变均值逐渐降低，而蓝色领域百分比逐渐增高，结果具有统计学意义（ P均＜0．05）。spearman相关性分析显示，肝纤维化病理分期与组织应变均值存在显著负相关关系（ r＝-0．931， P ＝0．000），与蓝色区域所占百分比存在显著正相关关系（ r ＝0．913， P ＝0．000）。结论超声弹性成像组织弥散定量作为一种无创监测技术能够间接判断肝纤维化病理分期的程度，值得在临床上广泛应用，对肝病患者疾病的评估及早期预防性治疗，具有重要意义。Objective To investigate the application of quantitative analysis of tissue diffusion in the degree of liver fibrosis so as to provide methods for liver condition of the patient assessment and early prevention .Methods 150 cases of chronic hepatitis B were selected in our hospital between January ,2011 to July ,2013 .Five periods （S0 - S4） were divided according to liver fibrosis staging standards after liver puncture .Another 40 healthy volunteers were selected as the control group .All subjects were analyzed by ultrasound imaging with tissue diffusion quantitative technology .11 tissue dispersion characteristic quantities between experimental group and the control group of subjects were compared .And the statistically significant indicators were compared in the patients with different pathological staging .Correlation was analyzed between them and the pathological staging .Results Among the 11 elastic characteristic quantities ,the average relative strain value in the experimental group was significantly lower than that in the control group （ P 〈0 .05） .The percentage of blue area in the experimental group was significantly higher than that in the control group （ P 〈0 .05） .Patients in the test group , with the increased of liver fibrosis staging ,the mean strain was gradually decreasing ,while the percentage of blue sphere was gradually increasing （ P 〈0 .05） .Spearman correlation analysis showed that there was a significant negative correlation between staging of liver fibrosis and tissue strain mean （ r =-0 .931 ,P =0 .000） .There was a significantly positive correlation between Liver fibrosis stage and the percentage of blue area （ r=0 .913 ,P=0.000） .Conclusion Quantitative diffusion elasto-sonography organization as a noninvasive monitoring technology can indirectly determine the degree of liver fibrosis staging .It deserves wide application in clinica .Its assessment of patients with liver disease and early treatment is important .

关 键 词：肝纤维化 超声弹性成像 组织弥散定量分析 

分 类 号：R575[医药卫生—消化系统] R445.1[医药卫生—内科学]