中国人近视与原发性开角型青光眼相关性的Meta分析  

Meta-analysis of association between myopia and primary open angle glaucoma

作　　者：项勇刚[1] 夏凌云[2] 张勇[1] 曾宪涛[3] 许玲[1] 

机构地区：[1]湖北医药学院附属太和医院眼科,湖北十堰442000 [2]湖北医药学院附属太和医院口腔科,湖北十堰442000 [3]湖北医药学院附属太和医院循证医学中心,湖北十堰442000

出　　处：《临床眼科杂志》2014年第3期259-262,共4页Journal of Clinical Ophthalmology

摘　　要：采用Meta分析的方法探讨中国人近视与原发性开角型青光眼（ POAG）的相关性。方法检索CNKI和VIP数据库中自建库至2013年7月20日之间公开发表的文献，对符合纳入标准的研究进行数据提取之后，采用Comprehensive Meta Analysis （ CMA） v2．2软件进行 Meta分析。结果最终纳入5个研究，其中3个研究将高度近视作为暴露因素单独列出来。 Meta分析结果显示，暴露于近视的人群罹患POAG的风险增加3．07倍（OR ＝3．07，95％CI ＝1．90-4．96；P ＜0．01）；暴露于高度近视者（屈光度数＞-6．0 D），罹患POAG的风险增加7．15倍（OR ＝7．15，95％CI ＝4．01-12．75；P ＜0．01）。敏感性分析显示结果稳健性好，未行发表偏倚分析。结论当前证据表明近视很可能是开角型青光眼的一个独立的、有意义的危险因素，并且高度近视者罹患POAG的风险高。Objective To explore the association between myopia and primary open angle glaucoma （ POAG） by Meta-analysis.Methods Relevant studies, published up to July 20, 2013, were searched from CNKI and VIP databases . After data extraction, a meta-analysis was performed using CMA （comprehensive meta analysis） v2.2 software.Results Five studies were finally recruited , including 3 studies that reported the association between myopia and POAG independ-ently.The results of meta-analysis showed that myopia evidently increases the risk of POAG by 3.07 times （ OR=3.07, 95%CI=1.90-4.96）, and high myopia obviously increases the risk of POAG by 7.15 times （OR=7.15, 95% CI=4.01-12.75）.Sensitivity analysis showed that the results were robust .The publication bias analysis was not conducted . Conclusion Based on the current evidence , myopia is probably an independent and significant risk factor for POAG , and the high myopia persons were with higher risk for POAG .

关 键 词：近视 原发型开角型青光眼 危险因素 META分析 

分 类 号：R778.11[医药卫生—眼科] R775[医药卫生—临床医学]